Cell line · CVCL_0286

H9c2(2-1)

Spontaneously immortalized cell line, Rattus norvegicus. 69 papers.

4 sourcescell-lines-2026-11-14-0.1.0

Cite this record

ConductScience Library. H9c2(2-1). Cell lines, record CVCL_0286. Release cell-lines-2026-11-14-0.1.0, 14 Nov 2026. https://conductscience.org/library/cell-lines/CVCL_0286

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Cell line

As Cellosaurus gives it.

Name: H9c2(2-1)
Accession: CVCL_0286
RRID: RRID:CVCL_0286
Synonyms: H9c2 (2-1), H9c2, H9C2
Species: Rattus norvegicus (Rat)
Sex: Sex unspecified
Age at sampling: Embryo
Category: Spontaneously immortalized cell line
Derived from: Embryonic heart, cardiac muscle (in situ)
Entry created: 2012-04-04
Entry updated: 2025-04-10

Source Cellosaurus

Problems0

Cellosaurus records no problem for this cell line.

None in this release.

Papers69

Paper	Journal	Year	How we know	Source
HydroMg attenuates doxorubicin-induced myocardial injury via promoting mitochondrial function.	Med Gas Res	2027	Its Methods give the RRID and name the line	PubMed
The role of cardiomyocytic FOXP3 and extracellular vesicle-mediated delivery of FOXP3 into cardiomyocytes for treating pathological cardiac hypertrophy.	Acta Pharm Sin B	2026	Its Methods give the RRID and name the line	PubMed
LGR6 couples maresin 1 signaling to glycolytic flux and protein lactylation for the rescue of diabetic cardiomyopathy.	J Diabetes Investig	2026	Its Methods give the RRID and name the line	PubMed
Colombiains A-C, Three New Alkaloids From the Soft Coral-Derived Fungus Cladosporium colombiae CSGL 10M10.	Chem Biodivers	2026	Its Methods give the RRID and name the line	PubMed
GPR55 Inhibits Inflammatory Factor TNF-α-Mediated RhoA/ROCK2/IκBα/p65 Signaling Pathway to Alleviate Diabetic Cardiomyopathy in Rats.	Int J Gen Med	2026	Its Methods give the RRID and name the line	PubMed
The Cavβ4 subunit of Cav1.2 channels antagonizes isoproterenol-induced hypertrophy in rat cardiac muscle cells by down-regulating miR-183-5p.	Physiol Rep	2026	Its Methods give the RRID and name the line	PubMed
Dose-Dependent Genome-Wide DNA Methylation Remodeling by Metformin Modulates Doxorubicin Sensitivity in Cardiac Cells.	Epigenomes	2026	Its Methods give the RRID and name the line	PubMed
SDF-1 loaded dECM patch improves cardiac function in rats after myocardial ischemia.	Stem Cell Res Ther	2026	Its Methods give the RRID and name the line	PubMed
Propofol and Salvianolic Acid a Synergistically Attenuate LPS-Induced Myocardial Pyroptosis in Diabetic Mice via the SIRT1/HMGB1 Pathway.	Mediators Inflamm	2026	Its Methods give the RRID and name the line	PubMed
Empagliflozin-pretreated mesenchymal stem cell-derived extracellular vesicles facilitate cardiac repair via AGGF1.	J Nanobiotechnology	2026	Its Methods give the RRID and name the line	PubMed

1 to 10 of 69

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Relatives24

Relation	Cell line	Accession	Source
Derived from it	H9C2(2-1)-Luc	CVCL_C8V4	Cell lines
Derived from it	H9C2(2-1)-Luc2-tdT	CVCL_XE64	Cell lines
Derived from it	H9C2(2-1)-mCherry	CVCL_XE65	Cell lines
Derived from it	H9C2(2-1)-tdT	CVCL_XE66	Cell lines
Derived from it	H9c2 Trpm4 KO	CVCL_B0FS	Cell lines
Derived from it	HyCyte H9c2(2-1) KO-rCpt1a	CVCL_E1JX	Cell lines
Derived from it	HyCyte H9c2(2-1) KO-rLOC102549962	CVCL_F1NZ	Cell lines
Derived from it	HyCyte H9c2(2-1) KO-rMapk1	CVCL_E1JY	Cell lines
Derived from it	HyCyte H9c2(2-1) stable cell line for rCtnnb1 overexpression	CVCL_F4PA	Cell lines
Derived from it	HyCyte H9c2(2-1) stable cell line for rKeap1 overexpression	CVCL_F4Q8	Cell lines

1 to 10 of 24

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Cell banks11

Cell bank	Catalog number	Source
ATCC	CRL-1446	ATCC
AddexBio	C0031002/5017	Cellosaurus
BCRC	60096	BCRC
BCRJ	0098	BCRJ
CCTCC	GDC0606	Cellosaurus
CLS	305203	CLS
ECACC	88092904	ECACC
IZSLER	BS CL 151	Cellosaurus
KCLB	21446	KCLB
NCBI_Iran	C585	Cellosaurus

1 to 10 of 11

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Data dates

The date of each source this release read.

Cellosaurus: 2026-10-22; Cellosaurus
PubMed Central's articles: 2026-11-12; PubMed Central's articles
Our copy of PubMed: 2026-11-06; Our copy of PubMed

Sources 4

CellosaurusCC BY 4.0, with credit to Cellosaurus (SIB)
PubMed Central's articlesTitles shown only for CC0, CC BY and public domain articles
NLM's PMC Article DatasetsCourtesy of NLM, which does not endorse this database
PubMedNLM's terms

Each source's terms

CellosaurusCC BY 4.0. Cellosaurus's README: "we have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) license to Cellosaurus (https://creativecommons.org/licenses/by/4.0/). This means that you are free to copy and redistribute Cellosaurus in any medium or format. You can remix, transform, and build upon Cellosaurus for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made." Copyright (c) CALIPHO group, SIB Swiss Institute of Bioinformatics. Read on 14 Nov 2026 at https://ftp.expasy.org/databases/cellosaurus/README
PubMed Central's articlesEach article's own license. Its words show only under CC0, CC BY or public domain
NLM's PMC Article DatasetsNLM's PMC Article Datasets on AWS, https://registry.opendata.aws/ncbi-pmc. Its terms: users "acknowledge NLM as the source of the data in a clear and conspicuous manner", do not use the PubMed Central wordmark or the PMC logo, do not "indicate or imply that NLM/NIH/HHS has endorsed" a product, and "only distribute data that are licensed for redistribution". Each article keeps its own license: https://pmc.ncbi.nlm.nih.gov/about/copyright/
PubMedNLM's terms

Cellosaurus, SIB Swiss Institute of Bioinformatics, https://www.cellosaurus.org, CC BY 4.0. Its problem notes are given in its own words.

For software

Read this cell line from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/cell-lines/v1/CVCL_0286

GET https://conductscience.org/api/cell-lines/v1/CVCL_0286/papers?page=2

API reference For AI assistants