Cell line · CVCL_0363

JEG-3

Cancer cell line, Homo sapiens. Gestational choriocarcinoma. 42 papers.

4 sourcescell-lines-2026-11-14-0.1.0

Cite this record

ConductScience Library. JEG-3. Cell lines, record CVCL_0363. Release cell-lines-2026-11-14-0.1.0, 14 Nov 2026. https://conductscience.org/library/cell-lines/CVCL_0363

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Cell line

As Cellosaurus gives it.

Name: JEG-3
Accession: CVCL_0363
RRID: RRID:CVCL_0363
Synonyms: Jeg-3, JEG3, Jeg3, jeg3
Species: Homo sapiens (Human)
Sex: Male
Age at sampling: Fetus
Category: Cancer cell line
Diseases: Gestational choriocarcinoma (NCIt C4646); Gestational choriocarcinoma (ORDO Orphanet_99926)
Derived from: Fetal brain (metastatic)
Entry created: 2012-04-04
Entry updated: 2026-06-25

Source Cellosaurus

Problems1

Problem	Cellosaurus's note
Caution	A TP53 mutation is indicated as being at p.Gln167His (c.501G>T) in PubMed=7819056 but has not been confirmed by CCLE and Cosmic-CLP.

Source Cellosaurus

Papers42

Paper	Journal	Year	How we know	Source
Molecular mechanisms underlying the effectiveness of triiodothyroacetic acid (Triac) in patients with resistance to thyroid hormone β (RTHβ): a multicentre, international, retrospective cohort study.	EBioMedicine	2026	Its Methods give the RRID and name the line	PubMed
A fully human pan VL9 HLA-E TCRm antibody enables functional dissection of HLA-E biology and checkpoint signaling.	iScience	2026	Its Methods give the RRID and name the line	PubMed
SR-B1-Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis.	Adv Sci (Weinh)	2026	Its Methods give the RRID and name the line	PubMed
Selective Targeting of Immune Checkpoints HLA-G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity.	Adv Sci (Weinh)	2026	Its Methods give the RRID and name the line	PubMed
HRS Degradation-Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal-Fetal Immune Homeostasis.	Adv Sci (Weinh)	2026	Its Methods give the RRID and name the line	PubMed
TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1.	Adv Sci (Weinh)	2026	Its Methods give the RRID and name the line	PubMed
Atosiban-conjugated 3WJ-pRNA nanoparticles delivering GAS1-enhanced extracellular vesicles: targeting the decidua to combat recurrent miscarriage.	J Nanobiotechnology	2025	Its Methods give the RRID and name the line	PubMed
A triple-action PROTAC for wild-type p53 cancer therapy.	Cell Rep Med	2025	Its Methods give the RRID and name the line	PubMed
Derivation of AZD5335, a Novel FRα-Targeted TOP1i-Loaded ADC, for the Treatment of FRα-Expressing Cancers.	Clin Cancer Res	2025	Its Methods give the RRID and name the line	PubMed
Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration.	Nat Commun	2025	Its Methods give the RRID and name the line	PubMed

1 to 10 of 42

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Relatives10

Relation	Cell line	Accession	Problem	Source
Derived from it	AC1 [Human gestational choriocarcinoma]	CVCL_9559		Cell lines
Derived from it	HyCyte JEG-3 KO-hB2M	CVCL_E1LL		Cell lines
Derived from it	HyCyte JEG-3 KO-hHLA-F	CVCL_F4J2		Cell lines
Derived from it	HyCyte JEG-3 KO-hLUM	CVCL_D6BV		Cell lines
Derived from it	HyCyte JEG-3 KO-hLUM(Lumican)	CVCL_F4HI		Cell lines
Derived from it	HyCyte JEG-3 KO-hMAPKAPK2	CVCL_F1R4		Cell lines
Derived from it	JEG-3/A3-1A7	CVCL_IV65		Cell lines
Derived from it	JEG-3/VP16	CVCL_6922		Cell lines
Derived from it	TEC61	CVCL_7167	Has a recorded problem	Cell lines
From the same person	BeWo	CVCL_0044		Cell lines

Cell banks13

Cell bank	Catalog number	Source
ABM	T8976	ABM
ATCC	HTB-36	ATCC
AddexBio	C0030003/4940	Cellosaurus
BCRC	60428	BCRC
BCRJ	0123	BCRJ
CCTCC	GDC0320	Cellosaurus
CLS	300222	CLS
DSMZ	ACC-463	DSMZ
ECACC	92120308	ECACC
Hysigen	TCH-C417	Hysigen

1 to 10 of 13

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Data dates

The date of each source this release read.

Cellosaurus: 2026-10-22; Cellosaurus
PubMed Central's articles: 2026-11-12; PubMed Central's articles
Our copy of PubMed: 2026-11-06; Our copy of PubMed

Sources 4

CellosaurusCC BY 4.0, with credit to Cellosaurus (SIB)
PubMed Central's articlesTitles shown only for CC0, CC BY and public domain articles
NLM's PMC Article DatasetsCourtesy of NLM, which does not endorse this database
PubMedNLM's terms

Each source's terms

CellosaurusCC BY 4.0. Cellosaurus's README: "we have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) license to Cellosaurus (https://creativecommons.org/licenses/by/4.0/). This means that you are free to copy and redistribute Cellosaurus in any medium or format. You can remix, transform, and build upon Cellosaurus for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made." Copyright (c) CALIPHO group, SIB Swiss Institute of Bioinformatics. Read on 14 Nov 2026 at https://ftp.expasy.org/databases/cellosaurus/README
PubMed Central's articlesEach article's own license. Its words show only under CC0, CC BY or public domain
NLM's PMC Article DatasetsNLM's PMC Article Datasets on AWS, https://registry.opendata.aws/ncbi-pmc. Its terms: users "acknowledge NLM as the source of the data in a clear and conspicuous manner", do not use the PubMed Central wordmark or the PMC logo, do not "indicate or imply that NLM/NIH/HHS has endorsed" a product, and "only distribute data that are licensed for redistribution". Each article keeps its own license: https://pmc.ncbi.nlm.nih.gov/about/copyright/
PubMedNLM's terms

Cellosaurus, SIB Swiss Institute of Bioinformatics, https://www.cellosaurus.org, CC BY 4.0. Its problem notes are given in its own words.

For software

Read this cell line from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/cell-lines/v1/CVCL_0363

GET https://conductscience.org/api/cell-lines/v1/CVCL_0363/papers?page=2

API reference For AI assistants