Cell line · CVCL_0434

MKN45

Cancer cell line, Homo sapiens. Gastric adenocarcinoma. 119 papers.

4 sourcescell-lines-2026-11-14-0.1.0

Cite this record

ConductScience Library. MKN45. Cell lines, record CVCL_0434. Release cell-lines-2026-11-14-0.1.0, 14 Nov 2026. https://conductscience.org/library/cell-lines/CVCL_0434

On this page

Cell line

As Cellosaurus gives it.

Name: MKN45
Accession: CVCL_0434
RRID: RRID:CVCL_0434
Synonyms: MKN-45, MKN 45
Species: Homo sapiens (Human)
Sex: Female
Age at sampling: 62Y
Category: Cancer cell line
Diseases: Gastric adenocarcinoma (NCIt C4004)
Derived from: Liver (metastatic)
Entry created: 2012-04-04
Entry updated: 2026-06-25

Source Cellosaurus

Problems1

Problem	Cellosaurus's note
Caution	Was indicated not to have a TP53 mutation in PubMed=1370612 and PubMed=15900046.

Source Cellosaurus

Papers119

Paper	Journal	Year	How we know	Source
Neuro-associated SEMA3C+ tumour cells promote gastric cancer peritoneal metastasis via EBF2-FGF7-FGFR2-mediated tumour-endothelial crosstalk.	Clin Transl Med	2026	Its Methods give the RRID and name the line	PubMed
Human lung explants as a predictive platform for evaluating the on-target, off-tumor toxicity of T cell bispecifics.	iScience	2026	Its Methods give the RRID and name the line	PubMed
Calcitriol alleviates ARID2-deficient gastric cancer metastasis via inhibition of the Wnt/β-catenin signaling pathway.	Transl Oncol	2026	Its Methods give the RRID and name the line	PubMed
Fast tumor accumulation and payload release of c-Met targeting aptamer-drug conjugate enables robust anti-tumor efficacy.	Cell Rep Med	2026	Its Methods give the RRID and name the line	PubMed
METTL3-Mediated m6A Modification of COL5A2 Inhibits Ferroptosis Through an IGF2BP3-dependent Mechanism in Gastric Cancer.	Technol Cancer Res Treat	2026	Its Methods give the RRID and name the line	PubMed
METTL7A Downregulation Drives SLC1A5-Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer.	Adv Sci (Weinh)	2026	Its Methods give the RRID and name the line	PubMed
Combining fruquintinib with TAS-102 as a promising strategy: antitumor activity in preclinical colorectal and gastric cancer xenograft models.	BMC Cancer	2026	Its Methods give the RRID and name the line	PubMed
TMEM97 regulates cholesterol biosynthesis and mitochondrial metabolism in gastric carcinoma.	iScience	2026	Its Methods give the RRID and name the line	PubMed
Framework for evaluating in vitro vasculogenic mimicry using structural and metabolic parameters.	Cell Rep Methods	2026	Its Methods give the RRID and name the line	PubMed
Long non-coding RNA SOCS2-AS1 inhibits gastric cancer progression via the miR-324-3p/GRIK3 axis: a mechanistic study.	World J Surg Oncol	2026	Its Methods give the RRID and name the line	PubMed

1 to 10 of 119

See all 119 papers

Relatives23

Relation	Cell line	Accession	Source
Derived from it	EDITGENE MKN-45-Cas9	CVCL_F5PK	Cell lines
Derived from it	EDITGENE MKN45-CopGFP	CVCL_F5ZI	Cell lines
Derived from it	EDITGENE MKN45-FLUC	CVCL_F5S1	Cell lines
Derived from it	GTL-16	CVCL_7668	Cell lines
Derived from it	HyCyte MKN45 KO-hCEACAM5	CVCL_F4F0	Cell lines
Derived from it	HyCyte MKN45 KO-hEDAR	CVCL_F1RY	Cell lines
Derived from it	HyCyte MKN45 KO-hSORCS2	CVCL_E1M7	Cell lines
Derived from it	HyCyte MKN45 stable cell line for hALPP overexpression	CVCL_F4M5	Cell lines
Derived from it	HyCyte MKN45 stable cell line for hPIK3R1 overexpression	CVCL_F4V4	Cell lines
Derived from it	HyCyte MKN45-Luc	CVCL_E3I1	Cell lines

1 to 10 of 23

See all 23 relatives

Cell banks10

Cell bank	Catalog number	Source
CCTCC	GDC0220	Cellosaurus
CLS	300489	CLS
DSMZ	ACC-409	DSMZ
EDITGENE	EDC00192	EDITGENE
Hysigen	TCH-C397	Hysigen
IBRC	C10137	Cellosaurus
JCRB	JCRB0254	JCRB
KCLB	80103	KCLB
NCBI_Iran	C615	Cellosaurus
RCB	RCB1001	RCB

Data dates

The date of each source this release read.

Cellosaurus: 2026-10-22; Cellosaurus
PubMed Central's articles: 2026-11-12; PubMed Central's articles
Our copy of PubMed: 2026-11-06; Our copy of PubMed

Sources 4

CellosaurusCC BY 4.0, with credit to Cellosaurus (SIB)
PubMed Central's articlesTitles shown only for CC0, CC BY and public domain articles
NLM's PMC Article DatasetsCourtesy of NLM, which does not endorse this database
PubMedNLM's terms

Each source's terms

CellosaurusCC BY 4.0. Cellosaurus's README: "we have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) license to Cellosaurus (https://creativecommons.org/licenses/by/4.0/). This means that you are free to copy and redistribute Cellosaurus in any medium or format. You can remix, transform, and build upon Cellosaurus for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made." Copyright (c) CALIPHO group, SIB Swiss Institute of Bioinformatics. Read on 14 Nov 2026 at https://ftp.expasy.org/databases/cellosaurus/README
PubMed Central's articlesEach article's own license. Its words show only under CC0, CC BY or public domain
NLM's PMC Article DatasetsNLM's PMC Article Datasets on AWS, https://registry.opendata.aws/ncbi-pmc. Its terms: users "acknowledge NLM as the source of the data in a clear and conspicuous manner", do not use the PubMed Central wordmark or the PMC logo, do not "indicate or imply that NLM/NIH/HHS has endorsed" a product, and "only distribute data that are licensed for redistribution". Each article keeps its own license: https://pmc.ncbi.nlm.nih.gov/about/copyright/
PubMedNLM's terms

Cellosaurus, SIB Swiss Institute of Bioinformatics, https://www.cellosaurus.org, CC BY 4.0. Its problem notes are given in its own words.

For software

Read this cell line from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/cell-lines/v1/CVCL_0434

GET https://conductscience.org/api/cell-lines/v1/CVCL_0434/papers?page=2

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