Cell line · CVCL_0485

PLC/PRF/5

Cancer cell line, Homo sapiens. Adult hepatocellular carcinoma. 103 papers.

4 sourcescell-lines-2026-11-14-0.1.0

Cite this record

ConductScience Library. PLC/PRF/5. Cell lines, record CVCL_0485. Release cell-lines-2026-11-14-0.1.0, 14 Nov 2026. https://conductscience.org/library/cell-lines/CVCL_0485

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Cell line

As Cellosaurus gives it.

Name: PLC/PRF/5
Accession: CVCL_0485
RRID: RRID:CVCL_0485
Synonyms: PLC-PRF-5, PLC PRF 5, PLC/PRF5, PLCPRF5, PLC-8024, PLC8024, PLC, Alexander cells, Alexander, Primary Liver Carcinoma/Poliomyelitis Research Foundation/5
Species: Homo sapiens (Human)
Sex: Male
Age at sampling: 24Y
Category: Cancer cell line
Diseases: Adult hepatocellular carcinoma (NCIt C7956); Adult hepatocellular carcinoma (ORDO Orphanet_210159)
Derived from: Liver (in situ)
Secondary accessions: CVCL_6714
Entry created: 2012-04-04
Entry updated: 2026-06-25

Source Cellosaurus

Problems1

Problem	Cellosaurus's note
Caution	Often called PLC8024 in Chinese literature probably because of a concatenation between PLC/PRF/5 and ATCC-8024.

Source Cellosaurus

Papers103

2 more articles give this line's RRID in its Methods without naming the line nearby, so they are not listed.

Paper	Journal	Year	How we know	Source
Multi-omics-driven personalized management of advanced HCC.	Cell Rep Med	2026	Its Methods give the RRID and name the line	PubMed
RNF180 loss stabilizes BCAS4 to enhance PD-L1 expression and immune evasion in hepatocellular carcinoma.	iScience	2026	Its Methods give the RRID and name the line	PubMed
FKBP52 dictates the dual role of p53 in hepatocellular carcinoma: Mutation-specific prognostic stratification and therapeutic implications.	J Biol Chem	2026	Its Methods give the RRID and name the line	PubMed
Epigenetic silencing of the liver-specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation.	Mol Oncol	2026	Its Methods give the RRID and name the line	PubMed
TrxR1 inhibition sensitizes hepatocellular carcinoma to Motesanib via an autophagy-ROS-JNK/ER stress axis.	Biol Direct	2026	Its Methods give the RRID and name the line	PubMed
ISX-TWIST1 reprograms CD47-inflammasome signaling to reshape the immune microenvironment in liver cancer.	Exp Hematol Oncol	2026	Its Methods give the RRID and name the line	PubMed
CCT2 Orchestrates Glycolysis and Exosome-Mediated M2 Macrophage Polarization in HCC tumorigenesis.	Int J Biol Sci	2026	Its Methods give the RRID and name the line	PubMed
Base Editing of TIGIT Reprograms CD155 Signaling in Natural Killer Cells to Enhance Cancer Immunotherapy Efficacy.	Cancer Res	2026	Its Methods give the RRID and name the line	PubMed
H4K5 lactylation - ENO2 loop drives glycolysis and HCC progression.	JHEP Rep	2026	Its Methods give the RRID and name the line	PubMed
scResponse: A Rank-Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single-Cell Data.	Adv Sci (Weinh)	2026	Its Methods give the RRID and name the line	PubMed

1 to 10 of 103

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Relatives16

Relation	Cell line	Accession	Source
Derived from it	HyCyte PLC/PRF/5 stable cell line for hMFSD2A overexpression	CVCL_F4RP	Cell lines
Derived from it	N1380	CVCL_A8RU	Cell lines
Derived from it	NPLC/PRF/5	CVCL_B449	Cell lines
Derived from it	PLC/PRF/5 Luciferase/GFP	CVCL_LJ87	Cell lines
Derived from it	PLC/PRF/5-Cas9-705	CVCL_XB32	Cell lines
Derived from it	PLC/PRF/5-Cas9-706	CVCL_XB33	Cell lines
Derived from it	PLC/PRF/5-Cas9-707	CVCL_XB34	Cell lines
Derived from it	PLC/PRF/5-Cas9-708	CVCL_XB35	Cell lines
Derived from it	PLC/PRF/5-Cas9-709	CVCL_XB36	Cell lines
Derived from it	PLC/PRF/5-Cas9-710	CVCL_XB37	Cell lines

1 to 10 of 16

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Cell banks15

Cell bank	Catalog number	Source
ATCC	CRL-8024	ATCC
BCRC	60223	BCRC
BCRJ	0274	BCRJ
CLS	300315	CLS
ECACC	85061113	ECACC
Hysigen	TCH-C298	Hysigen
IZSLER	BS TCL 122	Cellosaurus
JCRB	IFO50069	JCRB
JCRB	JCRB0406	JCRB
KCB	KCB 200785YJ	Cellosaurus

1 to 10 of 15

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Data dates

The date of each source this release read.

Cellosaurus: 2026-10-22; Cellosaurus
PubMed Central's articles: 2026-11-12; PubMed Central's articles
Our copy of PubMed: 2026-11-06; Our copy of PubMed

Sources 4

CellosaurusCC BY 4.0, with credit to Cellosaurus (SIB)
PubMed Central's articlesTitles shown only for CC0, CC BY and public domain articles
NLM's PMC Article DatasetsCourtesy of NLM, which does not endorse this database
PubMedNLM's terms

Each source's terms

CellosaurusCC BY 4.0. Cellosaurus's README: "we have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) license to Cellosaurus (https://creativecommons.org/licenses/by/4.0/). This means that you are free to copy and redistribute Cellosaurus in any medium or format. You can remix, transform, and build upon Cellosaurus for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made." Copyright (c) CALIPHO group, SIB Swiss Institute of Bioinformatics. Read on 14 Nov 2026 at https://ftp.expasy.org/databases/cellosaurus/README
PubMed Central's articlesEach article's own license. Its words show only under CC0, CC BY or public domain
NLM's PMC Article DatasetsNLM's PMC Article Datasets on AWS, https://registry.opendata.aws/ncbi-pmc. Its terms: users "acknowledge NLM as the source of the data in a clear and conspicuous manner", do not use the PubMed Central wordmark or the PMC logo, do not "indicate or imply that NLM/NIH/HHS has endorsed" a product, and "only distribute data that are licensed for redistribution". Each article keeps its own license: https://pmc.ncbi.nlm.nih.gov/about/copyright/
PubMedNLM's terms

Cellosaurus, SIB Swiss Institute of Bioinformatics, https://www.cellosaurus.org, CC BY 4.0. Its problem notes are given in its own words.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/cell-lines/v1/CVCL_0485

GET https://conductscience.org/api/cell-lines/v1/CVCL_0485/papers?page=2

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