Cell line · CVCL_1859
CCRF-HSB-2
Cancer cell line, Homo sapiens. Childhood T acute lymphoblastic leukemia. Cellosaurus records it as partially contaminated. 38 papers.
4 sourcescell-lines-2026-11-14-0.1.0
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Cite this record
ConductScience Library. CCRF-HSB-2. Cell lines, record CVCL_1859. Release cell-lines-2026-11-14-0.1.0, 14 Nov 2026. https://conductscience.org/library/cell-lines/CVCL_1859
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Cell line
As Cellosaurus gives it.
- Name
- CCRF-HSB-2
- Accession
- CVCL_1859
- RRID
- RRID:CVCL_1859
- Synonyms
- CCRF HSB-2, CCRF-HSB2, HSB-2, HSB.2, HSB2, H-SB2, SB-2, HSB, H.S.B., GM04155
- Species
- Homo sapiens (Human)
- Sex
- Male
- Age at sampling
- 11Y
- Category
- Cancer cell line
- Diseases
- Childhood T acute lymphoblastic leukemia (NCIt C7953); Precursor T-cell acute lymphoblastic leukemia (ORDO Orphanet_99861)
- Derived from
- Peripheral blood (in situ)
- Cell type
- T-cell
- Secondary accessions
- CVCL_5938
- Entry created
- 2012-04-04
- Entry updated
- 2025-04-10
Source Cellosaurus
Problems1
| Problem | Cellosaurus's note |
|---|---|
| Partially contaminated | The stock formerly distributed by CLS under catalog number 300214 was contaminated. Compared to the STR values obtained by other distributors it differed from having: Amelogenin: X; CSF1PO: 8,12; D16S539: 9,13,14; D18S51: 9,13,14; D21S11: 28,29; D7S820: 10,14; D8S1179: 9,15; FGA: 22,23,24; Penta D: 9; Penta E: 6,13 and TH01: 8,10. |
Source Cellosaurus
Papers38
| Paper | Journal | Year | How we know | Retracted | Source |
|---|---|---|---|---|---|
| Multiomics Profiling of T-cell Leukemia and Lymphoma Enables Targeted Therapeutic Discovery. | Cancer Res | 2026 | Its Methods give the RRID and name the line | PubMed | |
| Targeting the tumor cell-intrinsic ITGB2 axis inhibits melanoma progression. | Mol Cancer | 2025 | Its Methods give the RRID and name the line | PubMed | |
| Efficacy of NAMPT inhibition in T-cell acute lymphoblastic leukemia. | PLoS One | 2025 | Its Methods give the RRID and name the line | PubMed | |
| Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines. | Nat Commun | 2022 | Cellosaurus cites it | PubMed | |
| High accuracy mutation detection in leukemia on a selected panel of cancer genes. | PLoS One | 2012 | Cellosaurus cites it | PubMed | |
| Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes. | Leukemia | 2007 | Cellosaurus cites it | PubMed | |
| Authenticity and drug resistance in a panel of acute lymphoblastic leukaemia cell lines. | Br J Cancer | 2006 | Cellosaurus cites it | PubMed | |
| Correlation between DNA alterations and p53 and p16 protein expression in cancer cell lines. | Pathol Res Pract | 2005 | Cellosaurus cites it | PubMed | |
| Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. | Science | 2004 | Cellosaurus cites it | PubMed | |
| FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. | Blood | 2004 | Cellosaurus cites it | PubMed |
1 to 10 of 38
See all 38 papersRelatives5
| Relation | Cell line | Accession | Problem | Source |
|---|---|---|---|---|
| Derived from it | HSB.2-A7-D2 | CVCL_A0DR | Cell lines | |
| Derived from it | HSB.2-A7-D9 | CVCL_A0DS | Cell lines | |
| Derived from it | HSB.2-C5-B2 | CVCL_A0DT | Cell lines | |
| Derived from it | HSB2/GS | CVCL_1Y12 | Cell lines | |
| From the same person | CCRF-SB | CVCL_1860 | Cell lines |
Cell banks11
| Cell bank | Catalog number | Status | Source |
|---|---|---|---|
| ATCC | CCL-120.1 | ATCC | |
| BEI_Resources | ARP-497 | BEI_Resources | |
| CLS | 300214 | Discontinued | Cellosaurus |
| Coriell | GM04155 | Coriell | |
| DSMZ | ACC-435 | DSMZ | |
| ECACC | 85112801 | ECACC | |
| IZSLER | BS TCL 185 | Cellosaurus | |
| JCRB | JCRB0031 | JCRB | |
| KCLB | 10120.1 | KCLB | |
| NCBI_Iran | C530 | Cellosaurus |
1 to 10 of 11
See all 11 cell banksData dates
The date of each source this release read.
Sources 4
- CellosaurusCC BY 4.0, with credit to Cellosaurus (SIB)
- PubMed Central's articlesTitles shown only for CC0, CC BY and public domain articles
- NLM's PMC Article DatasetsCourtesy of NLM, which does not endorse this database
- PubMedNLM's terms
Each source's terms
- CellosaurusCC BY 4.0. Cellosaurus's README: "we have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) license to Cellosaurus (https://creativecommons.org/licenses/by/4.0/). This means that you are free to copy and redistribute Cellosaurus in any medium or format. You can remix, transform, and build upon Cellosaurus for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made." Copyright (c) CALIPHO group, SIB Swiss Institute of Bioinformatics. Read on 14 Nov 2026 at https://ftp.expasy.org/databases/cellosaurus/README
- PubMed Central's articlesEach article's own license. Its words show only under CC0, CC BY or public domain
- NLM's PMC Article DatasetsNLM's PMC Article Datasets on AWS, https://registry.opendata.aws/ncbi-pmc. Its terms: users "acknowledge NLM as the source of the data in a clear and conspicuous manner", do not use the PubMed Central wordmark or the PMC logo, do not "indicate or imply that NLM/NIH/HHS has endorsed" a product, and "only distribute data that are licensed for redistribution". Each article keeps its own license: https://pmc.ncbi.nlm.nih.gov/about/copyright/
- PubMedNLM's terms
Cellosaurus, SIB Swiss Institute of Bioinformatics, https://www.cellosaurus.org, CC BY 4.0. Its problem notes are given in its own words.
For software
Read this cell line from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/cell-lines/v1/CVCL_1859
GET https://conductscience.org/api/cell-lines/v1/CVCL_1859/papers?page=2