Cell line · CVCL_3509
ES-2
Cancer cell line, Homo sapiens. Ovarian clear cell adenocarcinoma. Cellosaurus records it as probably misclassified. 80 papers.
4 sourcescell-lines-2026-11-14-0.1.0
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Cite this record
ConductScience Library. ES-2. Cell lines, record CVCL_3509. Release cell-lines-2026-11-14-0.1.0, 14 Nov 2026. https://conductscience.org/library/cell-lines/CVCL_3509
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Cell line
As Cellosaurus gives it.
- Name
- ES-2
- Accession
- CVCL_3509
- RRID
- RRID:CVCL_3509
- Synonyms
- ES2
- Species
- Homo sapiens (Human)
- Sex
- Female
- Age at sampling
- 47Y
- Category
- Cancer cell line
- Diseases
- Ovarian clear cell adenocarcinoma (NCIt C40078); Clear cell adenocarcinoma of the ovary (ORDO Orphanet_398971)
- Derived from
- Ovary (in situ)
- Entry created
- 2012-04-04
- Entry updated
- 2026-06-25
Source Cellosaurus
Problems1
| Problem | Cellosaurus's note |
|---|---|
| Probably misclassified | It is dubious that this cell line originates from an African American 47 year old patient diagnosed with an ovarian clear cell adenocarcinoma. Immunohistochemical and qPCR analysis as well as its mutational profile support an ovarian serous adenocarcinoma origin (PubMed=25049276; DOI=10.26502/ogr072). Furthermore its genome ancestry clearly shows a Caucasian/European decent (PubMed=30894373) which is confirmed by mtDNA haplotyping (DOI=10.26502/ogr072). |
Source Cellosaurus
Papers80
| Paper | Journal | Year | How we know | Retracted | Source |
|---|---|---|---|---|---|
| ERX-208 Induces Endoplasmic Reticulum Stress and Suppresses DNA Damage Repair to Enhance Chemotherapy Sensitivity. | Cancer Res Commun | 2026 | Its Methods give the RRID and name the line | PubMed | |
Enhanced expression of ADAMTS1 in ovarian carcinomas: loss of ADAMTS1 expression instigates cellular reprogramming of extracellular matrix ensuing altered plasticity, augmented migration and attenuated adhesion. | J Biomed Sci | 2026 | Its Methods give the RRID and name the line | PubMed | |
| Metabolic activation of LDHA by ERRα represses inflammasome-dependent pyroptosis and promotes ovarian cancer chemoresistance. | Cell Death Dis | 2026 | Its Methods give the RRID and name the line | PubMed | |
| The central precocious puberty-associated gene MKRN3 is a tumor suppressor regulating CSDE1 ubiquitination in ovarian cancer. | Oncogenesis | 2026 | Its Methods give the RRID and name the line | PubMed | |
| Targeting the CHD3 chromatin remodeler exploits a synthetic lethal vulnerability in dual SMARCA4/SMARCA2-deficient cancers via derepression of PARD3B. | NPJ Precis Oncol | 2026 | Its Methods give the RRID and name the line | PubMed | |
| RHOV Is a Detachment-Responsive Rho GTPase Necessary for Ovarian Cancer Peritoneal Metastasis. | Cancer Res | 2026 | Its Methods give the RRID and name the line | PubMed | |
| BMAL2 is a druggable target for ovarian clear cell carcinoma (OCCC). | EMBO Mol Med | 2026 | Its Methods give the RRID and name the line | PubMed | |
| A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy. | Cell | 2026 | Its Methods give the RRID and name the line | PubMed | |
| Identification and Experimental Validation of Triosephosphate Isomerase 1 as a Functional Biomarker of SHetA2 Sensitivity in Ovarian Cancer. | Cells | 2026 | Its Methods give the RRID and name the line | PubMed | |
| Mesothelial cells promote peritoneal invasion and metastasis of ascites-derived ovarian cancer cells through spheroid formation. | Sci Adv | 2026 | Its Methods give the RRID and name the line | PubMed |
1 to 10 of 80
See all 80 papersRelatives7
| Relation | Cell line | Accession | Problem | Source |
|---|---|---|---|---|
| Derived from it | ES-2/GFP | CVCL_JY93 | Has a recorded problem | Cell lines |
| Derived from it | ES-2/T80 | CVCL_CZ94 | Has a recorded problem | Cell lines |
| Derived from it | ES-2/TxT50 | CVCL_CZ95 | Has a recorded problem | Cell lines |
| Derived from it | ES-2R | CVCL_M715 | Has a recorded problem | Cell lines |
| Derived from it | ES2/GFP | CVCL_E8YD | Has a recorded problem | Cell lines |
| Derived from it | ES2/Luciferase | CVCL_E8YE | Has a recorded problem | Cell lines |
| Derived from it | ES2/Luciferase-2A-GFP | CVCL_E8YF | Has a recorded problem | Cell lines |
Cell banks8
| Cell bank | Catalog number | Status | Source |
|---|---|---|---|
| ATCC | CRL-1978 | ATCC | |
| AddexBio | C0017006/4971 | Cellosaurus | |
| BCRC | 60067 | BCRC | |
| BCRJ | 0080 | BCRJ | |
| CCTCC | GDC0322 | Cellosaurus | |
| CLS | 305038 | CLS | |
| Hysigen | TCH-C596 | Hysigen | |
| Ubigene | YC-C139 | Ubigene |
Data dates
The date of each source this release read.
Sources 4
- CellosaurusCC BY 4.0, with credit to Cellosaurus (SIB)
- PubMed Central's articlesTitles shown only for CC0, CC BY and public domain articles
- NLM's PMC Article DatasetsCourtesy of NLM, which does not endorse this database
- PubMedNLM's terms
Each source's terms
- CellosaurusCC BY 4.0. Cellosaurus's README: "we have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) license to Cellosaurus (https://creativecommons.org/licenses/by/4.0/). This means that you are free to copy and redistribute Cellosaurus in any medium or format. You can remix, transform, and build upon Cellosaurus for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made." Copyright (c) CALIPHO group, SIB Swiss Institute of Bioinformatics. Read on 14 Nov 2026 at https://ftp.expasy.org/databases/cellosaurus/README
- PubMed Central's articlesEach article's own license. Its words show only under CC0, CC BY or public domain
- NLM's PMC Article DatasetsNLM's PMC Article Datasets on AWS, https://registry.opendata.aws/ncbi-pmc. Its terms: users "acknowledge NLM as the source of the data in a clear and conspicuous manner", do not use the PubMed Central wordmark or the PMC logo, do not "indicate or imply that NLM/NIH/HHS has endorsed" a product, and "only distribute data that are licensed for redistribution". Each article keeps its own license: https://pmc.ncbi.nlm.nih.gov/about/copyright/
- PubMedNLM's terms
Cellosaurus, SIB Swiss Institute of Bioinformatics, https://www.cellosaurus.org, CC BY 4.0. Its problem notes are given in its own words.
For software
Read this cell line from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/cell-lines/v1/CVCL_3509
GET https://conductscience.org/api/cell-lines/v1/CVCL_3509/papers?page=2