Cell line · CVCL_A537
NCI-H249
Cancer cell line, Homo sapiens. Lung small cell carcinoma. Cellosaurus records it as contaminated. 14 papers.
4 sourcescell-lines-2026-11-14-0.1.0
Download JSON
Cite this record
ConductScience Library. NCI-H249. Cell lines, record CVCL_A537. Release cell-lines-2026-11-14-0.1.0, 14 Nov 2026. https://conductscience.org/library/cell-lines/CVCL_A537
On this page
Cell line
As Cellosaurus gives it.
- Name
- NCI-H249
- Accession
- CVCL_A537
- RRID
- RRID:CVCL_A537
- Synonyms
- H249, H-249, NCIH249
- Species
- Homo sapiens (Human)
- Sex
- Male
- Age at sampling
- 55Y
- Category
- Cancer cell line
- Diseases
- Lung small cell carcinoma (NCIt C4917); Small cell lung cancer (ORDO Orphanet_70573)
- Derived from
- Pleural effusion (metastatic)
- Parent
- NCI-H69 (CVCL_1579)
- Entry created
- 2012-06-06
- Entry updated
- 2025-04-10
Source Cellosaurus
Problems1
| Problem | Cellosaurus's note |
|---|---|
| Contaminated | Shown to be a NCI-H69 derivative (PubMed=20143388). Originally thought to originate from the bone marrow of a male patient with small cell lung cancer. |
Source Cellosaurus
Papers14
| Paper | Journal | Year | How we know | Retracted | Source |
|---|---|---|---|---|---|
| Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets. | Clin Epigenetics | 2020 | Cellosaurus cites it | PubMed | |
| From clinical specimens to human cancer preclinical models-a journey the NCI-cell line database-25 years later. | J Cell Biochem | 2020 | Cellosaurus cites it | PubMed | |
| Small cell lung carcinoma cell line screen of etoposide/carboplatin plus a third agent. | Cancer Med | 2017 | Cellosaurus cites it | PubMed | |
| Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression. | J Natl Cancer Inst | 2016 | Cellosaurus cites it | PubMed | |
| Check your cultures! A list of cross-contaminated or misidentified cell lines. | Int J Cancer | 2010 | Cellosaurus cites it | PubMed | |
| Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer. | Oncogene | 2000 | Cellosaurus cites it | PubMed | |
| MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer. | J Cell Biochem Suppl | 1996 | Cellosaurus cites it | PubMed | |
| NCI-Navy Medical Oncology Branch cell line data base. | J Cell Biochem Suppl | 1996 | Cellosaurus cites it | PubMed | |
| Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines. | Pathobiology | 1992 | Cellosaurus cites it | PubMed | |
| Novel antigens characteristic of neuroendocrine malignancies. | Cancer | 1991 | Cellosaurus cites it | PubMed |
1 to 10 of 14
See all 14 papersRelatives1
| Relation | Cell line | Accession | Problem |
|---|---|---|---|
| Parent | NCI-H69 | CVCL_1579 |
Source Cell lines
Cell banks2
| Cell bank | Catalog number | Status |
|---|---|---|
| ATCC | CRL-5827 | Discontinued |
| KCLB | 90249 | Discontinued |
Source Cellosaurus
Data dates
The date of each source this release read.
Sources 4
- CellosaurusCC BY 4.0, with credit to Cellosaurus (SIB)
- PubMed Central's articlesTitles shown only for CC0, CC BY and public domain articles
- NLM's PMC Article DatasetsCourtesy of NLM, which does not endorse this database
- PubMedNLM's terms
Each source's terms
- CellosaurusCC BY 4.0. Cellosaurus's README: "we have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) license to Cellosaurus (https://creativecommons.org/licenses/by/4.0/). This means that you are free to copy and redistribute Cellosaurus in any medium or format. You can remix, transform, and build upon Cellosaurus for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made." Copyright (c) CALIPHO group, SIB Swiss Institute of Bioinformatics. Read on 14 Nov 2026 at https://ftp.expasy.org/databases/cellosaurus/README
- PubMed Central's articlesEach article's own license. Its words show only under CC0, CC BY or public domain
- NLM's PMC Article DatasetsNLM's PMC Article Datasets on AWS, https://registry.opendata.aws/ncbi-pmc. Its terms: users "acknowledge NLM as the source of the data in a clear and conspicuous manner", do not use the PubMed Central wordmark or the PMC logo, do not "indicate or imply that NLM/NIH/HHS has endorsed" a product, and "only distribute data that are licensed for redistribution". Each article keeps its own license: https://pmc.ncbi.nlm.nih.gov/about/copyright/
- PubMedNLM's terms
Cellosaurus, SIB Swiss Institute of Bioinformatics, https://www.cellosaurus.org, CC BY 4.0. Its problem notes are given in its own words.
For software
Read this cell line from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/cell-lines/v1/CVCL_A537
GET https://conductscience.org/api/cell-lines/v1/CVCL_A537/problems