Cell line · CVCL_F6LY
MCF-10A PTEN(-/-)
Spontaneously immortalized cell line, Homo sapiens. 2 papers.
4 sourcescell-lines-2026-11-14-0.1.0
Cite this record
ConductScience Library. MCF-10A PTEN(-/-). Cell lines, record CVCL_F6LY. Release cell-lines-2026-11-14-0.1.0, 14 Nov 2026. https://conductscience.org/library/cell-lines/CVCL_F6LY
On this page
Cell line
As Cellosaurus gives it.
- Name
- MCF-10A PTEN(-/-)
- Accession
- CVCL_F6LY
- RRID
- RRID:CVCL_F6LY
- Synonyms
- PTEN-/−
- Species
- Homo sapiens (Human)
- Sex
- Female
- Age at sampling
- 36Y
- Category
- Spontaneously immortalized cell line
- Derived from
- Breast, epithelium (in situ)
- Parent
- MCF-10A PTEN(+/-) (CVCL_F6LX)
- Entry created
- 2026-10-22
- Entry updated
- 2026-10-22
Source Cellosaurus
Problems0
Cellosaurus records no problem for this cell line.
None in this release.
Papers2
| Paper | Journal | Year | How we know | Retracted | Source |
|---|---|---|---|---|---|
| The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence. | Oncotarget | 2015 | Cellosaurus cites it | PubMed | |
| Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells. | Cancer Res | 2009 | Cellosaurus cites it | PubMed |
Relatives4
| Relation | Cell line | Accession | Problem | Source |
|---|---|---|---|---|
| Parent | MCF-10A PTEN(+/-) | CVCL_F6LX | Cell lines | |
| Derived from it | MCF10A PTEN-/- KRas(G12V) clone 1 | CVCL_F6KS | Cell lines | |
| Derived from it | MCF10A PTEN-/- KRas(G12V) clone 2 | CVCL_F6KU | Cell lines | |
| Derived from it | PTEN-/-Luc | CVCL_F6KY | Cell lines |
Cell banks0
None in this release.
Data dates
The date of each source this release read.
Sources 4
- CellosaurusCC BY 4.0, with credit to Cellosaurus (SIB)
- PubMed Central's articlesTitles shown only for CC0, CC BY and public domain articles
- NLM's PMC Article DatasetsCourtesy of NLM, which does not endorse this database
- PubMedNLM's terms
Each source's terms
- CellosaurusCC BY 4.0. Cellosaurus's README: "we have chosen to apply the Creative Commons Attribution 4.0 International (CC BY 4.0) license to Cellosaurus (https://creativecommons.org/licenses/by/4.0/). This means that you are free to copy and redistribute Cellosaurus in any medium or format. You can remix, transform, and build upon Cellosaurus for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made." Copyright (c) CALIPHO group, SIB Swiss Institute of Bioinformatics. Read on 14 Nov 2026 at https://ftp.expasy.org/databases/cellosaurus/README
- PubMed Central's articlesEach article's own license. Its words show only under CC0, CC BY or public domain
- NLM's PMC Article DatasetsNLM's PMC Article Datasets on AWS, https://registry.opendata.aws/ncbi-pmc. Its terms: users "acknowledge NLM as the source of the data in a clear and conspicuous manner", do not use the PubMed Central wordmark or the PMC logo, do not "indicate or imply that NLM/NIH/HHS has endorsed" a product, and "only distribute data that are licensed for redistribution". Each article keeps its own license: https://pmc.ncbi.nlm.nih.gov/about/copyright/
- PubMedNLM's terms
Cellosaurus, SIB Swiss Institute of Bioinformatics, https://www.cellosaurus.org, CC BY 4.0. Its problem notes are given in its own words.
For software
Read this cell line from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/cell-lines/v1/CVCL_F6LY
GET https://conductscience.org/api/cell-lines/v1/CVCL_F6LY/problems