Comparison · NCT00003644-sae
Paclitaxel + Carboplatin Followed 4 Weeks Later by Paclitaxel vs Paclitaxel + Carboplatin Followed by Observation: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Paclitaxel + Carboplatin Followed 4 Weeks Later by Paclitaxel vs Paclitaxel + Carboplatin Followed by Observation: serious adverse events. Trial comparisons, record NCT00003644-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00003644-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0255 | 0.0124 | 0.0518 | wilson | |
| Risk in group 2 | 0.0187 | 0.00799 | 0.0429 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00689 | -0.0207 | 0.0352 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.37 | 0.44 | 4.26 | log | |
| Odds ratio, group 1 over group 2 | 1.38 | 0.432 | 4.4 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Paclitaxel + Carboplatin Followed 4 Weeks Later by Paclitaxel than on Paclitaxel + Carboplatin Followed by Observation | 145 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Paclitaxel + Carboplatin Followed 4 Weeks Later by Paclitaxel | Paclitaxel 175 mg/m2 IV over 3 hours, Carboplatin AUC=6 IV every 21 days x 3 cycles Followed 4 weeks later by paclitaxel 40 mg/m2 over 1 hour every week for 24 weeks | 7 | 274 | EG000 |
| Group 2 | Paclitaxel + Carboplatin Followed by Observation | Paclitaxel 175 mg/m2 IV over 3 hours, Carboplatin AUC=6 IV every 21 days x 3 cycles, followed by observation | 5 | 268 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Up to 24 weeks
Source ClinicalTrials.gov
Trial
- Title
- Carboplatin Plus Paclitaxel With or Without Continued Low-Dose Paclitaxel in Treating Patients With Early-Stage Ovarian Cancer
- NCT number
- NCT00003644
- Phases
- PHASE3
- Conditions
- Ovarian Cancer
- Interventions
- carboplatin, paclitaxel
- Lead sponsor
- Gynecologic Oncology Group
- Results first posted
- 2019-04-17
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00003644?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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