Comparison · NCT00004124-deaths
Arm I: Bicalutamide + Goserelin vs Arm II: Mitoxantrone + Prednisone + Bivalutamid + Goserelin: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Arm I: Bicalutamide + Goserelin vs Arm II: Mitoxantrone + Prednisone + Bivalutamid + Goserelin: deaths from any cause. Trial comparisons, record NCT00004124-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00004124-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.181 | 0.149 | 0.219 | wilson | |
| Risk in group 2 | 0.198 | 0.164 | 0.237 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0166 | -0.0671 | 0.0339 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.916 | 0.702 | 1.2 | log | |
| Odds ratio, group 1 over group 2 | 0.898 | 0.646 | 1.25 | log | |
| Number needed to treat, for one fewer death from any cause on Arm I: Bicalutamide + Goserelin than on Arm II: Mitoxantrone + Prednisone + Bivalutamid + Goserelin | 60.3 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Arm I: Bicalutamide + Goserelin | Patients receive goserelin subcutaneously once every 13 weeks (8 injections total) and oral bicalutamide once daily for 2 years in the absence of disease progression or unacceptable toxicity. | 85 | 469 | EG000 |
| Group 2 | Arm II: Mitoxantrone + Prednisone + Bivalutamid + Goserelin | Patients receive mitoxantrone IV over 30 minutes on day 1 and oral prednisone twice daily on days 1-21. Treatment repeats every 3 weeks for 6 courses in the absence of disease progression or unacceptable toxicity. Patients also receive hormonal therapy as in arm I beginning concurrently with the initiation of mitoxantrone and prednisone. | 91 | 460 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Arm 1 assessed every 3 months up through 22 months; Arm 2 assessed every 21 days through first four months, and then every 3 months through 22 months
Source ClinicalTrials.gov
Trial
- Title
- S9921, Hormone Therapy With or Without Mitoxantrone and Prednisone in Patients Who Have Undergone Radical Prostatectomy for Prostate Cancer
- NCT number
- NCT00004124
- Phases
- PHASE3
- Conditions
- Prostate Cancer
- Interventions
- bicalutamide, goserelin, mitoxantrone hydrochloride, prednisone
- Lead sponsor
- SWOG Cancer Research Network
- Results first posted
- 2018-09-04
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00004124?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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