Comparison · NCT00017953-34339585
Lifestyle Intervention vs Diabetes Support and Education: First Occurrence of Major Clinical Events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Lifestyle Intervention vs Diabetes Support and Education: First Occurrence of Major Clinical Events. Trial comparisons, record NCT00017953-34339585. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00017953-34339585
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.225 | 0.209 | 0.241 | wilson | |
| Risk in group 2 | 0.233 | 0.217 | 0.25 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0085 | -0.0314 | 0.0145 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.964 | 0.872 | 1.07 | log | |
| Odds ratio, group 1 over group 2 | 0.953 | 0.837 | 1.09 | log | |
| Number needed to treat, for one fewer participant with the outcome on Lifestyle Intervention than on Diabetes Support and Education | 118 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Lifestyle Intervention | Participants in the lifestyle intervention arm are offered individual and group sessions designed to help achieve and maintain weight loss.~Lifestyle Intervention: The lifestyle intervention is implemented with individual supervision and group sessions and is aimed at achieving and maintaining at least a 7% decrease in weight from baseline and 175 minutes per week in physical activity. It is implemented during a four-year period with the most intensive application during the first year, less frequent attention during the next three years, and a minimum of twice yearly contacts during an extended follow-up period. To help participants achieve and maintain weight loss, a variety of diet strategies (e.g. prepared meals and liquid formula), exercise strategies, and optional weight loss medications are utilized based on a preset algorithm and participant progress. | 577 | 2,570 | OG000 |
| Group 2 | Diabetes Support and Education | The diabetes support and education arm provides group sessions on diabetes management and social support.~Diabetes Support and Education: Participants assigned to diabetes support and education are offered three sessions each year in diabetes management and social support. | 600 | 2,575 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- First Occurrence of Major Clinical Events
- Description
Number of participants with first occurrence of one of the following: death (all causes), myocardial infarction, stroke, hospitalization for angina, coronary artery bypass grafting, percutaneous coronary angioplasty, hospitalization for congestive heart failure, carotid endarterectomy, or peripheral vascular procedures such as bypass or angioplasty
- Time frame
- up to 11 years
- Population
- Intent to treat, all randomized participants
Source ClinicalTrials.gov
Trial
- Title
- Look AHEAD: Action for Health in Diabetes
- NCT number
- NCT00017953
- Phases
- NA
- Conditions
- Diabetes, Myocardial Infarction, Stroke, Kidney Diseases, Bone Diseases, Dyslipidemia
- Interventions
- Lifestyle Intervention, Diabetes Support and Education
- Lead sponsor
- Wake Forest University Health Sciences
- Results first posted
- 2023-08-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00017953?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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