Comparison · NCT00017953-89b1a9d5
Lifestyle Intervention vs Diabetes Support and Education: First Occurrence of a Severe Cardiovascular Event
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Lifestyle Intervention vs Diabetes Support and Education: First Occurrence of a Severe Cardiovascular Event. Trial comparisons, record NCT00017953-89b1a9d5. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00017953-89b1a9d5
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.157 | 0.143 | 0.171 | wilson | |
| Risk in group 2 | 0.162 | 0.149 | 0.177 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00552 | -0.0255 | 0.0145 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.966 | 0.852 | 1.1 | log | |
| Odds ratio, group 1 over group 2 | 0.96 | 0.827 | 1.11 | log | |
| Number needed to treat, for one fewer participant with the outcome on Lifestyle Intervention than on Diabetes Support and Education | 181 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Lifestyle Intervention | Participants in the lifestyle intervention arm are offered individual and group sessions designed to help achieve and maintain weight loss.~Lifestyle Intervention: The lifestyle intervention is implemented with individual supervision and group sessions and is aimed at achieving and maintaining at least a 7% decrease in weight from baseline and 175 minutes per week in physical activity. It is implemented during a four-year period with the most intensive application during the first year, less frequent attention during the next three years, and a minimum of twice yearly contacts during an extended follow-up period. To help participants achieve and maintain weight loss, a variety of diet strategies (e.g. prepared meals and liquid formula), exercise strategies, and optional weight loss medications are utilized based on a preset algorithm and participant progress. | 403 | 2,570 | OG000 |
| Group 2 | Diabetes Support and Education | The diabetes support and education arm provides group sessions on diabetes management and social support.~Diabetes Support and Education: Participants assigned to diabetes support and education are offered three sessions each year in diabetes management and social support. | 418 | 2,575 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- First Occurrence of a Severe Cardiovascular Event
- Description
Number of participants with first on-study occurrence of one of the following major cardiovascular events: fatal and non-fatal myocardial infarctions and strokes, hospitalizations for angina, and cardiovascular deaths
- Time frame
- up to 11 years
- Population
- Intent to Treat, all randomized participants
Source ClinicalTrials.gov
Trial
- Title
- Look AHEAD: Action for Health in Diabetes
- NCT number
- NCT00017953
- Phases
- NA
- Conditions
- Diabetes, Myocardial Infarction, Stroke, Kidney Diseases, Bone Diseases, Dyslipidemia
- Interventions
- Lifestyle Intervention, Diabetes Support and Education
- Lead sponsor
- Wake Forest University Health Sciences
- Results first posted
- 2023-08-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00017953?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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