Comparison · NCT00045162-sae
Cisplatin + Irinotecan vs Cisplatin + Etoposide: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Cisplatin + Irinotecan vs Cisplatin + Etoposide: serious adverse events. Trial comparisons, record NCT00045162-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00045162-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.333 | 0.284 | 0.387 | wilson | |
| Risk in group 2 | 0.0948 | 0.0676 | 0.131 | wilson | |
| Risk difference, group 1 minus group 2 | 0.239 | 0.177 | 0.298 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 3.52 | 2.43 | 5.08 | log | |
| Odds ratio, group 1 over group 2 | 4.77 | 3.08 | 7.39 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Cisplatin + Irinotecan than on Cisplatin + Etoposide | 4.19 | 3.35 | 5.65 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Cisplatin + Irinotecan | 107 | 321 | EG000 | |
| Group 2 | Cisplatin + Etoposide | 31 | 327 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Patients were evaluated for adverse events prior to the beginning of each cycle of treatment, approximately every 4 weeks, for up to a maximum of 4 cycles (16 weeks).
Source ClinicalTrials.gov
Trial
- Title
- S0124: Cisplatin Combined With Irinotecan or Etoposide For Extensive-Stage Small Cell Lung Cancer
- NCT number
- NCT00045162
- Phases
- PHASE3
- Conditions
- Lung Cancer
- Interventions
- cisplatin, etoposide, irinotecan hydrochloride
- Lead sponsor
- SWOG Cancer Research Network
- Results first posted
- 2013-07-09
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00045162?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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GET https://conductscience.org/api/comparisons/v1/NCT00045162-sae