LDCT Screening vs CXR Screening: Lung Cancer Deaths
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.0133 | 0.012 | 0.0148 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.0166 | 0.0151 | 0.0182 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.00325 | -0.00532 | -0.00119 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.804 | 0.7 | 0.923 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.801 | 0.696 | 0.922 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with the outcome on LDCT Screening than on CXR Screening | 308 | 188 | 838 | from the risk difference interval | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | LDCT Screening | Participants randomized to receive three annual low-dose helical CT exams of the chest. | 356 | 26,722 | OG000 | ClinicalTrials.gov |
| Group 2 | CXR Screening | Participants randomized to receive three annual chest radiographs. | 443 | 26,732 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | PRIMARY | ClinicalTrials.gov |
| Title | Lung Cancer Deaths | ClinicalTrials.gov |
| Description | Lung cancer deaths confirmed in participants by Endpoint Verification if available, otherwise by death certificate. | ClinicalTrials.gov |
| Time frame | All events through December 31, 2009; median follow-up 6.5 years. | ClinicalTrials.gov |
| Population | All participants randomized were analyzed. An intention-to-treat analysis was performed. | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | National Lung Screening Trial (NLST) Screening | ClinicalTrials.gov |
| NCT number | NCT00047385 | ClinicalTrials.gov |
| Phases | PHASE3 | ClinicalTrials.gov |
| Conditions | Lung Cancer | ClinicalTrials.gov |
| Interventions | low-dose helical computed tomography, chest radiography | ClinicalTrials.gov |
| Lead sponsor | National Cancer Institute (NCI) | ClinicalTrials.gov |
| Results first posted | 2012-07-06 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT00047385?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.