Comparison · NCT00061568-deaths
Participants With Severe Beta-globin Disorders in Allogeneic Peripheral Blood Stem Cell Transplants vs Human Leukocyte Antigens (HLA) Matched Related Stem Cell Donor: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Participants With Severe Beta-globin Disorders in Allogeneic Peripheral Blood Stem Cell Transplants vs Human Leukocyte Antigens (HLA) Matched Related Stem Cell Donor: deaths from any cause. Trial comparisons, record NCT00061568-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00061568-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0968 | 0.0451 | 0.195 | wilson | |
| Risk in group 2 | 0 | 0 | 0.0535 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0968 | 0.0224 | 0.195 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
Number needed to harm, for one more death from any cause on Participants With Severe Beta-globin Disorders in Allogeneic Peripheral Blood Stem Cell Transplants than on Human Leukocyte Antigens (HLA) Matched Related Stem Cell Donor | 10.3 | 5.12 | 44.6 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Participants With Severe Beta-globin Disorders in Allogeneic Peripheral Blood Stem Cell Transplants | Nonmyeloablative transplant regiment, consisting of alemtuzumab (1 mg/kg in divided doses), total-body irradiation (300 cGy), sirolimus, and infusion of unmanipulated filgrastim mobilized peripheral blood stem cells from human leukocyte antigen-matched siblings. | 6 | 62 | EG000 |
| Group 2 | Human Leukocyte Antigens (HLA) Matched Related Stem Cell Donor | Participants received filgrastim to mobilize peripheral blood stem cells for apheresis collection. Collected stem cells of donor will then be infused to HLA matched recipient of stem cell transplant. | 0 | 68 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Up to 5 years
Source ClinicalTrials.gov
Trial
- Title
- Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias
- NCT number
- NCT00061568
- Phases
- PHASE1, PHASE2
- Conditions
- Congenital Hemolytic Anemia, Sickle Cell Disease
- Interventions
- Peripheral blood hematopoietic progenitor cell (PBPC) transplant, Alemtuzumab, Peripheral blood hematopoietic progenitor cell Apheresis, Sirolimus
- Lead sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
- Results first posted
- 2024-02-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00061568?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
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GET https://conductscience.org/api/comparisons/v1/NCT00061568-deaths