Exemestane vs Anastrozole: Clinical Fracture Rate: Number of Participants With Bone Fractures.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.0945 | 0.0856 | 0.104 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.0935 | 0.0846 | 0.103 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | 0.00101 | -0.0122 | 0.0142 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 1.01 | 0.879 | 1.16 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 1.01 | 0.867 | 1.18 | log | ClinicalTrials.gov | |
| Number needed to treat, for one more participant with the outcome on Exemestane than on Anastrozole | 994 | from the risk difference interval | the interval includes no difference | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Exemestane | Patients receive oral exemestane (25 mg) once daily for 5 years.~exemestane: Given orally | 358 | 3,789 | OG000 | ClinicalTrials.gov |
| Group 2 | Anastrozole | Patients receive oral anastrozole (1 mg) once daily for 5 years.~anastrozole: Given orally | 354 | 3,787 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | SECONDARY | ClinicalTrials.gov |
| Title | Clinical Fracture Rate: Number of Participants With Bone Fractures. | ClinicalTrials.gov |
| Description | Clinical fracture at any time, including hip, spine, wrist fractures and other bone fractures. | ClinicalTrials.gov |
| Time frame | 8 years | ClinicalTrials.gov |
| Population | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | Exemestane or Anastrozole in Treating Postmenopausal Women Who Have Undergone Surgery for Primary Breast Cancer | ClinicalTrials.gov |
| NCT number | NCT00066573 | ClinicalTrials.gov |
| Phases | PHASE3 | ClinicalTrials.gov |
| Conditions | Breast Cancer | ClinicalTrials.gov |
| Interventions | anastrozole, exemestane | ClinicalTrials.gov |
| Lead sponsor | NCIC Clinical Trials Group | ClinicalTrials.gov |
| Results first posted | 2014-05-15 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT00066573?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.