Comparison · NCT00089479-sae
AC Then T vs AC Then XT: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. AC Then T vs AC Then XT: serious adverse events. Trial comparisons, record NCT00089479-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00089479-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.202 | 0.181 | 0.225 | wilson | |
| Risk in group 2 | 0.156 | 0.137 | 0.177 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0464 | 0.0169 | 0.0759 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.3 | 1.1 | 1.53 | log | |
| Odds ratio, group 1 over group 2 | 1.37 | 1.12 | 1.68 | log | |
| Number needed to harm, for one more participant with a serious adverse event on AC Then T than on AC Then XT | 21.5 | 13.2 | 59.3 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | AC Then T | Adriamycin 60 mg/m\^2 iv plus Cytoxan 600 mg/m\^2 iv repeat every 3 weeks for 4 cycles followed by Taxotere 100 mg/m\^2; repeat every 3 weeks for 4 cycles | 264 | 1,305 | EG000 |
| Group 2 | AC Then XT | Adriamycin 60 mg/m\^2 iv plus Cytoxan 600 mg/m\^2 iv repeat every 3 weeks for 4 cycles followed by Xeloda 825 mg/m\^2 po (bid) \[total daily dose is 1650 mg/m\^2\] Days 1-14 every 3 weeks for 4 cycles plus Taxotere 75 mg/m\^2 iv every 3 weeks for 4 cycles | 200 | 1,283 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Length of study
Source ClinicalTrials.gov
Trial
- Title
- A Study of Xeloda (Capecitabine) in Women With High-Risk Breast Cancer
- NCT number
- NCT00089479
- Phases
- PHASE3
- Conditions
- Breast Cancer
- Interventions
- capecitabine [Xeloda], Taxotere, Taxotere
- Lead sponsor
- Hoffmann-La Roche
- Results first posted
- 2011-06-23
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00089479?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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