Comparison · NCT00094770-e68faebf
Sitagliptin 100 mg vs Glipizide: Number of Participants With Drug-related LAEs at Week 104
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Sitagliptin 100 mg vs Glipizide: Number of Participants With Drug-related LAEs at Week 104. Trial comparisons, record NCT00094770-e68faebf. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00094770-e68faebf
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0306 | 0.0194 | 0.0479 | wilson | |
| Risk in group 2 | 0.036 | 0.0236 | 0.0543 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00535 | -0.0269 | 0.0159 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.851 | 0.458 | 1.58 | log | |
| Odds ratio, group 1 over group 2 | 0.847 | 0.446 | 1.61 | log | |
| Number needed to treat, for one fewer participant with the outcome on Sitagliptin 100 mg than on Glipizide | 187 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Sitagliptin 100 mg | The Sitagliptin 100 mg group includes data from patients randomized to receive treatment with 100 mg oral tablets of sitagliptin once daily. | 18 | 588 | OG000 |
| Group 2 | Glipizide | The Glipizide group includes data from patients randomized to receive treatment with glipizide initiated at a dose of 1 tablet (5 mg) per day. Patients could then up-titrated to a total daily dose of 4 tablets twice daily (20mg/day) based on their glycemic control. | 21 | 584 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Drug-related LAEs at Week 104
- Description
- Participants with drug-related (as assessed by an investigator who is a qualified physician according to his/her best clinical judgment) LAEs.
- Time frame
- Baseline to Week 104
- Population
- All randomized participants who received at least 1 dose of the double-blind study therapy.
Source ClinicalTrials.gov
Trial
- Title
- An Investigational Drug Study in Patients With Type 2 Diabetes Mellitus (0431-024)
- NCT number
- NCT00094770
- Phases
- PHASE3
- Conditions
- Diabetes Mellitus, Type 2
- Interventions
- sitagliptin (MK0431), Comparator: glipizide
- Lead sponsor
- Merck Sharp & Dohme LLC
- Results first posted
- 2009-12-22
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00094770?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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