Comparison · NCT00103142-d61087c7
PANVAC-V + PANVAC-F + DC vs PANVAC-V + PANVAC-F + GM-CSF: Recurrence-free Survival at 2 Years
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. PANVAC-V + PANVAC-F + DC vs PANVAC-V + PANVAC-F + GM-CSF: Recurrence-free Survival at 2 Years. Trial comparisons, record NCT00103142-d61087c7. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00103142-d61087c7
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.813 | 0.57 | 0.934 | wilson | |
| Risk in group 2 | 0.5 | 0.299 | 0.701 | wilson | |
| Risk difference, group 1 minus group 2 | 0.313 | -0.00235 | 0.547 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.63 | 0.988 | 2.67 | log | |
| Odds ratio, group 1 over group 2 | 4.33 | 0.937 | 20 | log | |
| Number needed to treat, for one more participant with the outcome on PANVAC-V + PANVAC-F + DC than on PANVAC-V + PANVAC-F + GM-CSF | 3.2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | PANVAC-V + PANVAC-F + DC | Patients undergo leukapheresis to obtain leukocytes for generation of autologous dendritic cells (DC). Patients then receive autologous DC loaded with vaccinia-carcinoembryonic antigen (CEA)- mucin 1 (MUC-1)-TRiad of Costimulatory Molecules (TRICOM) (PANVAC-V) vaccine subcutaneously (SC) and intradermally (ID) on day 1 and autologous DC loaded with fowlpox-CEA-MUC-1-TRICOM (PANVAC-F) vaccine subcutaneously (SC) and intradermally (ID) on days 28, 56, and 84. | 13 | 16 | OG000 |
| Group 2 | PANVAC-V + PANVAC-F + GM-CSF | Patients receive PANVAC-V SC on day 1 and PANVAC-F SC on days 28, 56, and 84. Patients also receive sargramostim (GM-CSF) subcutaneously (SC) into the same injection site once daily on days 0-3, 28-31, 56-59, and 84-87. | 10 | 20 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Recurrence-free Survival at 2 Years
- Description
Recurrence-free survival for randomized patients receiving dendritic cells (DC) loaded with PANVAC or PANVAC plus Granulocyte-macrophage colony-stimulating factor (GM-CSF) measured from the date of metastasectomy, with relapse defined as documented disease recurrence at any site.
- Time frame
- 2 years
- Population
Source ClinicalTrials.gov
Trial
- Title
- Vaccine Therapy in Treating Patients With Liver or Lung Metastases From Colorectal Cancer
- NCT number
- NCT00103142
- Phases
- PHASE2
- Conditions
- Colorectal Cancer, Metastatic Cancer
- Interventions
- falimarev, inalimarev, sargramostim, therapeutic autologous dendritic cells
- Lead sponsor
- Michael Morse, MD
- Results first posted
- 2014-04-07
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00103142?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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