Comparison · NCT00105534-ddcbe57b
AzaSite vs Vehicle: Participants Who Achieved Clinical Resolution
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. AzaSite vs Vehicle: Participants Who Achieved Clinical Resolution. Trial comparisons, record NCT00105534-ddcbe57b. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00105534-ddcbe57b
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.631 | 0.545 | 0.709 | wilson | |
| Risk in group 2 | 0.497 | 0.417 | 0.576 | wilson | |
| Risk difference, group 1 minus group 2 | 0.134 | 0.0174 | 0.245 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.27 | 1.03 | 1.56 | log | |
| Odds ratio, group 1 over group 2 | 1.73 | 1.07 | 2.8 | log | |
| Number needed to treat, for one more participant with the outcome on AzaSite than on Vehicle | 7.46 | 4.08 | 57.5 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: vehicle.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | AzaSite | 82 | 130 | OG000 | |
| Group 2 | Vehicle | 74 | 149 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Participants Who Achieved Clinical Resolution
- Description
- Clinical Resolution is defined as absence of all three clinical signs: ocular discharge, bulbar conjunctival injection, and palpebral conjunctival injection.
- Time frame
- Visit 3 (Days 6-7)
- Population
Per protocol population (defined as all randomized participants who had administered at least one drop of study drug, who had eye cultures indicating pathogenic bacteria levels as well as the clinical signs of conjunctivitis at Visit 1 and had at least one post first dose clinical assessment) with last observation carried forward.
Source ClinicalTrials.gov
Trial
- Title
- Evaluation of Clinical and Microbial Efficacy and Safety of AzaSite Compared to Vehicle for Bacterial Conjunctivitis (C-01-401-003)
- NCT number
- NCT00105534
- Phases
- PHASE3
- Conditions
- Bacterial Conjunctivitis
- Interventions
- AzaSite, Vehicle
- Lead sponsor
- Merck Sharp & Dohme LLC
- Results first posted
- 2011-10-27
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00105534?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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