Comparison · NCT00110890-dfaafda4
Cinacalcet vs Standard of Care: Number of Participants With Mean Ca x P < 55 mg^2/dL^2 and iPTH ≤ 300 pg/mL
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Cinacalcet vs Standard of Care: Number of Participants With Mean Ca x P < 55 mg^2/dL^2 and iPTH ≤ 300 pg/mL. Trial comparisons, record NCT00110890-dfaafda4. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00110890-dfaafda4
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.59 | 0.539 | 0.639 | wilson | |
| Risk in group 2 | 0.158 | 0.112 | 0.217 | wilson | |
| Risk difference, group 1 minus group 2 | 0.432 | 0.354 | 0.499 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 3.74 | 2.65 | 5.28 | log | |
| Odds ratio, group 1 over group 2 | 7.68 | 4.91 | 12 | log | |
| Number needed to treat, for one more participant with the outcome on Cinacalcet than on Standard of Care | 2.31 | 2 | 2.83 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: standard of care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Cinacalcet | Treatment with cinacalcet will be initiated at a dose of 30 mg/day. Possible daily doses of cinacalcet are 30, 60, 90, 120, and 180 mg. Dose escalation of cinacalcet may occur based on intact parathyroid hormone (iPTH) values. | 217 | 368 | OG000 |
| Group 2 | Standard of Care | Subjects randomised to the standard care arm are to receive appropriate therapy in accordance with the investigator's practice in an attempt to achieve the Kidney Disease Outcomes Quality Initiative (K/DOQI) parathyroid hormone (PTH), serum calcium, phosphorus, and Ca x P treatment targets. | 29 | 184 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Mean Ca x P < 55 mg^2/dL^2 and iPTH ≤ 300 pg/mL
- Description
- Number of participants with mean calcium x phosphorus (Ca x P) \< 55 mg\^2/dL\^2 and intact parathyroid hormone (iPTH) ≤ 300 pg/mL during the efficacy assessment phase
- Time frame
- Efficacy Assesment Phase (weeks 17-23)
- Population
- Full Analysis Set, composed of all randomized participants with imputation using modified last value carried forward (mLVCF)
Source ClinicalTrials.gov
Trial
- Title
- A Research Study for Patients With End-Stage Renal Disease (ESRD)
- NCT number
- NCT00110890
- Phases
- PHASE4
- Conditions
- End Stage Renal Disease
- Interventions
- cinacalcet, Standard of care
- Lead sponsor
- Amgen
- Results first posted
- 2011-03-07
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00110890?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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