Comparison · NCT00135707-db72a3e3
Vitamins vs Placebo: Analysis of Primary Composite Outcome in Participants Randomized on or After the 13th Week of Pregnancy
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Vitamins vs Placebo: Analysis of Primary Composite Outcome in Participants Randomized on or After the 13th Week of Pregnancy. Trial comparisons, record NCT00135707-db72a3e3. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00135707-db72a3e3
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0573 | 0.0493 | 0.0665 | wilson | |
| Risk in group 2 | 0.0561 | 0.0482 | 0.0653 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00111 | -0.011 | 0.0132 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.02 | 0.824 | 1.26 | log | |
| Odds ratio, group 1 over group 2 | 1.02 | 0.814 | 1.28 | log | |
| Number needed to treat, for one more participant with the outcome on Vitamins than on Placebo | 904 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Vitamins | 1000mg of Vitamin C and 400IU of Vitamin E per capsule, twice daily between randomization (at 9 to 16 weeks) up to delivery.~Dietary Supplement/Vitamins: Vitamin C (1000 mg) and Vitamin E (400 IU) per capsule, two capsules daily between randomization (at 9 - 16 weeks gestation) up to delivery. | 161 | 2,812 | OG000 |
| Group 2 | Placebo | Placebo capsules consisting of Mineral Oil, Hydrogenated Vegetable Oil, Lecithin, Yellow wax, Soft Gelatin Shell, twice daily between randomization (at 9 to 16 weks) up to delivery.~Placebo for Vitamin C and Vitamin E: Placebo two capsules daily between randomization (at 9 - 16 weeks gestation) up to delivery. | 158 | 2,814 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- POST_HOC
- Title
- Analysis of Primary Composite Outcome in Participants Randomized on or After the 13th Week of Pregnancy
- Description
Subgroup analysis of the primary composite outcome (severe pregnancy associated hypertension or severe or mild hypertension with elevated liver-enzyme levels, thrombocytopenia, elevated serum creatinine levels, eclamptic seizure, indicated preterm birth, fetal-growth restriction or prenatal death) in participants who were randomized on or after the 13th week of pregnancy.
- Time frame
- During pregnancy
- Population
Source ClinicalTrials.gov
Trial
- Title
- Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS)
- NCT number
- NCT00135707
- Phases
- PHASE3
- Conditions
- Preeclampsia
- Interventions
- Dietary Supplement/Vitamins, Placebo for Vitamin C and Vitamin E
- Lead sponsor
- The George Washington University Biostatistics Center
- Results first posted
- 2018-11-20
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00135707?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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