Comparison · NCT00135707-e3f20d64
Vitamins vs Placebo: Analysis of Primary Composite Outcome in Participants Randomized Before the 13th Week of Pregnancy
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Vitamins vs Placebo: Analysis of Primary Composite Outcome in Participants Randomized Before the 13th Week of Pregnancy. Trial comparisons, record NCT00135707-e3f20d64. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00135707-e3f20d64
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.066 | 0.0563 | 0.0772 | wilson | |
| Risk in group 2 | 0.0587 | 0.0496 | 0.0695 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00728 | -0.00716 | 0.0217 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.12 | 0.892 | 1.42 | log | |
| Odds ratio, group 1 over group 2 | 1.13 | 0.885 | 1.45 | log | |
| Number needed to treat, for one more participant with the outcome on Vitamins than on Placebo | 137 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Vitamins | Vitamins C \& E | 144 | 2,181 | OG000 |
| Group 2 | Placebo | Mineral Oil, Hydrogenated Vegetable Oil, Lecithin, Yellow wax, Soft Gelatin Shell | 127 | 2,162 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- POST_HOC
- Title
- Analysis of Primary Composite Outcome in Participants Randomized Before the 13th Week of Pregnancy
- Description
Subgroup analysis of the primary composite outcome (severe pregnancy associated hypertension or severe or mild hypertension with elevated liver-enzyme levels, thrombocytopenia, elevated serum creatinine levels, eclamptic seizure, indicated preterm birth, fetal-growth restriction or prenatal death) in participants who were randomized before the 13th week of pregnancy.
- Time frame
- During pregnancy
- Population
Source ClinicalTrials.gov
Trial
- Title
- Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS)
- NCT number
- NCT00135707
- Phases
- PHASE3
- Conditions
- Preeclampsia
- Interventions
- Dietary Supplement/Vitamins, Placebo for Vitamin C and Vitamin E
- Lead sponsor
- The George Washington University Biostatistics Center
- Results first posted
- 2018-11-20
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00135707?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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