Comparison · NCT00141102-82861d03
Celecoxib vs Oral Diclofenac Plus Omeprazole: Number of Subjects Withdrawn Due to GI Adverse Events (AEs)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Celecoxib vs Oral Diclofenac Plus Omeprazole: Number of Subjects Withdrawn Due to GI Adverse Events (AEs). Trial comparisons, record NCT00141102-82861d03. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00141102-82861d03
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0509 | 0.0426 | 0.0608 | wilson | |
| Risk in group 2 | 0.0744 | 0.0642 | 0.0859 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0234 | -0.0377 | -0.00924 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.685 | 0.544 | 0.863 | log | |
| Odds ratio, group 1 over group 2 | 0.668 | 0.523 | 0.854 | log | |
| Number needed to treat, for one fewer participant with the outcome on Celecoxib than on Oral Diclofenac Plus Omeprazole | 42.7 | 26.5 | 108 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Celecoxib | 200 mg BID plus omeprazole placebo and diclofenac SR placebo | 114 | 2,238 | OG000 |
| Group 2 | Oral Diclofenac Plus Omeprazole | Oral diclofenac SR (75 mg BID) plus omeprazole (20 mg QD) and celecoxib placebo. | 167 | 2,246 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Subjects Withdrawn Due to GI Adverse Events (AEs)
- Description
GI AEs were defined using MedDRA SOC Gastrointestinal Disorders but excluding the following HLGTs: Benign Neoplasms Gastrointestinal; Dental and Gingival Conditions; Oral Soft Tissue Conditions; Salivary Gland Conditions; and Tongue Conditions.
- Time frame
- 6 month treatment duration
- Population
- ITT
Source ClinicalTrials.gov
Trial
- Title
- Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis
- NCT number
- NCT00141102
- Phases
- PHASE4
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid
- Interventions
- Celecoxib, Diclofenac + Omeprazole
- Lead sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
- Results first posted
- 2010-06-11
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00141102?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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