Comparison · NCT00141102-eea04678
Celecoxib vs Oral Diclofenac Plus Omeprazole: Number of Subjects With a Clinically Significant Decrease From Baseline in Hematocrit and/or Hemoglobin
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Celecoxib vs Oral Diclofenac Plus Omeprazole: Number of Subjects With a Clinically Significant Decrease From Baseline in Hematocrit and/or Hemoglobin. Trial comparisons, record NCT00141102-eea04678. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00141102-eea04678
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0206 | 0.0154 | 0.0275 | wilson | |
| Risk in group 2 | 0.0568 | 0.0478 | 0.0673 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0362 | -0.0479 | -0.0249 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.363 | 0.259 | 0.508 | log | |
| Odds ratio, group 1 over group 2 | 0.35 | 0.247 | 0.495 | log | |
| Number needed to treat, for one fewer participant with the outcome on Celecoxib than on Oral Diclofenac Plus Omeprazole | 27.7 | 20.9 | 40.2 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Celecoxib | 200 mg BID plus omeprazole placebo and diclofenac SR placebo | 45 | 2,184 | OG000 |
| Group 2 | Oral Diclofenac Plus Omeprazole | Oral diclofenac SR (75 mg BID) plus omeprazole (20 mg once daily \[QD\]) and celecoxib placebo. | 123 | 2,167 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Subjects With a Clinically Significant Decrease From Baseline in Hematocrit and/or Hemoglobin
- Description
- A clinically significant decrease from baseline was defined as a fall in hematocrit \> = 10 percentage points and/or hemoglobin \> = 2 g/dL.
- Time frame
- 6 month treatment duration
- Population
- Safety population. Number of Participants Analyzed = number of subjects with analyzable data.
Source ClinicalTrials.gov
Trial
- Title
- Study Of Celecoxib Or Diclofenac And Omeprazole For Gastrointestinal (GI) Safety In High GI Risk Patients With Arthritis
- NCT number
- NCT00141102
- Phases
- PHASE4
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid
- Interventions
- Celecoxib, Diclofenac + Omeprazole
- Lead sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
- Results first posted
- 2010-06-11
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00141102?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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