Comparison · NCT00180271-sae
Cardiac Resynchronization Therapy + Defibrillator vs Implantable Cardioverter Defibrillator Alone: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Cardiac Resynchronization Therapy + Defibrillator vs Implantable Cardioverter Defibrillator Alone: serious adverse events. Trial comparisons, record NCT00180271-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00180271-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.152 | 0.132 | 0.175 | wilson | |
| Risk in group 2 | 0.0772 | 0.0598 | 0.0992 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0747 | 0.0449 | 0.103 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.97 | 1.47 | 2.63 | log | |
| Odds ratio, group 1 over group 2 | 2.14 | 1.55 | 2.95 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Cardiac Resynchronization Therapy + Defibrillator than on Implantable Cardioverter Defibrillator Alone | 13.4 | 9.68 | 22.3 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Cardiac Resynchronization Therapy + Defibrillator | Patients randomized to cardiac resynchronization therapy with backup defibrillation (CRT-D) in addition to optimal pharmacologic therapy (as administered by the primary care physician). CRT-D devices both deliver shocks to terminate potentially lethal ventricular arrhythmias and pace both ventricles in patients with ventricular dyssynchrony. | 164 | 1,079 | EG000 |
| Group 2 | Implantable Cardioverter Defibrillator Alone | Patients randomized to implantable cardioverter defibrillator (ICD) in addition to optimal pharmacologic therapy (as administered by the primary care physician). ICDs deliver shocks to terminate potentially lethal ventricular arrhythmias. | 55 | 712 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- 91 Days
Source ClinicalTrials.gov
Trial
- Title
- MADIT-CRT: Multicenter Automatic Defibrillator Implantation With Cardiac Resynchronization Therapy
- NCT number
- NCT00180271
- Phases
- NA
- Conditions
- Tachycardia, Congestive Heart Failure
- Interventions
- Cardiac resynchronization therapy with defibrillation, Implantable Cardioverter Defibrillator (ICD)
- Lead sponsor
- Boston Scientific Corporation
- Results first posted
- 2011-06-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00180271?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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