Comparison · NCT00246519-sae
Atenolol +HCTZ Arm vs HCTZ + Atenolol: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Atenolol +HCTZ Arm vs HCTZ + Atenolol: serious adverse events. Trial comparisons, record NCT00246519-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00246519-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00259 | 0.000457 | 0.0145 | wilson | |
| Risk in group 2 | 0.00785 | 0.00267 | 0.0228 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00526 | -0.0204 | 0.00775 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.33 | 0.0345 | 3.16 | log | |
| Odds ratio, group 1 over group 2 | 0.328 | 0.034 | 3.17 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Atenolol +HCTZ Arm than on HCTZ + Atenolol | 190 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Atenolol +HCTZ Arm | atenolol 50 mg, then 100 mg if BP \< 120/70, then add HCTZ 12.5 mg if BP \< 120/70, then HCTZ 25 mg if BP \< 120/70 | 1 | 386 | EG000 |
| Group 2 | HCTZ + Atenolol | HCTZ 12.5 mg then HCTZ 25 mg if BP \< 120/70, then add atenolol 50 mg if BP \< 120/70, then atenolol 100 mg if BP \< 120/70. | 3 | 382 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- Pharmacogenomic Evaluation of Antihypertensive Responses
- NCT number
- NCT00246519
- Phases
- PHASE4
- Conditions
- Hypertension
- Interventions
- Hydrochlorothiazide, Atenolol
- Lead sponsor
- University of Florida
- Results first posted
- 2013-07-10
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00246519?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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