Comparison · NCT00252733-331cc712
Candesartan vs Placebo: Number of Participants With a 2-step or Greater Increase in Early Treatment Diabetic Retinopathy Study (ETDRS) Severity Scale.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Candesartan vs Placebo: Number of Participants With a 2-step or Greater Increase in Early Treatment Diabetic Retinopathy Study (ETDRS) Severity Scale. Trial comparisons, record NCT00252733-331cc712. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00252733-331cc712
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.25 | 0.22 | 0.283 | wilson | |
| Risk in group 2 | 0.306 | 0.273 | 0.34 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0553 | -0.102 | -0.00869 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.819 | 0.692 | 0.97 | log | |
| Odds ratio, group 1 over group 2 | 0.759 | 0.601 | 0.958 | log | |
| Number needed to treat, for one fewer participant with the outcome on Candesartan than on Placebo | 18.1 | 9.85 | 115 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Candesartan | Candesartan cilexetil 32 mg once daily | 178 | 711 | OG000 |
| Group 2 | Placebo | Placebo Comparator | 217 | 710 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With a 2-step or Greater Increase in Early Treatment Diabetic Retinopathy Study (ETDRS) Severity Scale.
- Description
Two steps were defined as either a 1-step change in each eye or as a 2-step change in one eye only. ETDRS is a scale with 11 steps (1-11, where a score of 1 represents no retinopathy and a score of 11 represents proliferative retinopathy). A generalized log-rank test was used to test difference between treatments.
- Time frame
- From baseline to end of study, i.e. 5 years, with visits after a half year, one year and thereafter one visit per year.
- Population
- The population was the Intention To Treat population which includes all randomized patients with any post-randomization data.
Source ClinicalTrials.gov
Trial
- Title
- Diabetic Retinopathy Candesartan Trials
- NCT number
- NCT00252733
- Phases
- PHASE3
- Conditions
- Type 1 Diabetes
- Interventions
- candesartan cilexetil
- Lead sponsor
- AstraZeneca
- Results first posted
- 2012-04-13
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00252733?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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