Comparison · NCT00277355-sae
Minocycline 100 mg Twice Daily vs Matching Placebo Twice Daily: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Minocycline 100 mg Twice Daily vs Matching Placebo Twice Daily: serious adverse events. Trial comparisons, record NCT00277355-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00277355-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.126 | 0.0721 | 0.212 | wilson | |
| Risk in group 2 | 0.037 | 0.00657 | 0.183 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0894 | -0.0662 | 0.181 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 3.41 | 0.462 | 25.3 | log | |
| Odds ratio, group 1 over group 2 | 3.76 | 0.463 | 30.6 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Minocycline 100 mg Twice Daily than on Matching Placebo Twice Daily | 11.2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Minocycline 100 mg Twice Daily | Minocycline 100 mg/twice daily (minocycline to placebo 3:1 ratio randomization). | 11 | 87 | EG000 |
| Group 2 | Matching Placebo Twice Daily | Matching placebo twice daily (minocycline to placebo 3:1 ratio randomization. | 1 | 27 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Baseline to 18 months
Source ClinicalTrials.gov
Trial
- Title
- Pilot Study of Minocycline in Huntington's Disease
- NCT number
- NCT00277355
- Phases
- PHASE2, PHASE3
- Conditions
- Huntington Disease
- Interventions
- minocycline, Matching placebo
- Lead sponsor
- Merit Cudkowicz
- Results first posted
- 2013-04-19
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00277355?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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