Comparison · NCT00282984-de607912
Varenicline (Var) vs Placebo (Pbo): Number of Participants With a 4 Week Point Prevalence of Smoking Cessation
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Varenicline (Var) vs Placebo (Pbo): Number of Participants With a 4 Week Point Prevalence of Smoking Cessation. Trial comparisons, record NCT00282984-de607912. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00282984-de607912
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.28 | 0.236 | 0.329 | wilson | |
| Risk in group 2 | 0.163 | 0.128 | 0.205 | wilson | |
| Risk difference, group 1 minus group 2 | 0.118 | 0.0563 | 0.178 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.72 | 1.29 | 2.3 | log | |
| Odds ratio, group 1 over group 2 | 2 | 1.39 | 2.89 | log | |
| Number needed to treat, for one more participant with the outcome on Varenicline (Var) than on Placebo (Pbo) | 8.5 | 5.62 | 17.8 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Varenicline (Var) | 1 week titration followed by 11 weeks of 1 milligram (mg) twice daily (BID) dosing. Study medication was discontinued at the Week 12 visit and participants' smoking status was followed through the non-treatment period to Week 52. | 99 | 353 | OG000 |
| Group 2 | Placebo (Pbo) | 1 week titration followed by 11 weeks of placebo (pbo). Study medication was discontinued at the Week 12 visit and participants' smoking status was followed through the non-treatment period to Week 52. | 57 | 350 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With a 4 Week Point Prevalence of Smoking Cessation
- Description
Responders: participants with abstinence during the last 4 weeks of non-treatment based on answering 'no' to both of the two 'last 4 week' questions in the Nicotine Use Inventory (NUI). NUI collected information of cigarette or other nicotine use during the study.
- Time frame
- Week 48 through Week 52 (final 4 weeks of non-treatment period [pd])
- Population
- All Participants population
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety of Varenicline in Smokers With Cardiovascular Disease Who Wish to Quit Smoking
- NCT number
- NCT00282984
- Phases
- PHASE3
- Conditions
- Smoking Cessation
- Interventions
- placebo, Varenicline
- Lead sponsor
- Pfizer
- Results first posted
- 2009-04-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00282984?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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