Cangrelor Arm vs Clopidogrel Arm: Incidence of Abrupt Closure, Threatened Abrupt Closure, Need for Urgent Coronary Artery Bypass Graft (CABG) Surgery, or Unsuccessful Procedure During the Index PCI
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.0326 | 0.0275 | 0.0386 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.0364 | 0.031 | 0.0428 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.00384 | -0.012 | 0.00431 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.895 | 0.707 | 1.13 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.891 | 0.698 | 1.14 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with the outcome on Cangrelor Arm than on Clopidogrel Arm | 261 | from the risk difference interval | the interval includes no difference | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Cangrelor Arm | placebo capsules (to match) at PCI start + cangrelor bolus (30 mcg/kg) \& infusion (4 mcg/kg/min) administered from randomization for at least 2 hours, or until the end of the PCI, whichever is longer with the option to extend up to 4 hours maximum (per investigator discretion) + active clopidogrel (600mg) post infusion | 127 | 3,897 | OG000 | ClinicalTrials.gov |
| Group 2 | Clopidogrel Arm | clopidogrel capsules (600 mg) at PCI start + placebo bolus \& infusion (to match) followed by placebo capsules post infusion | 141 | 3,871 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | SECONDARY | ClinicalTrials.gov |
| Title | Incidence of Abrupt Closure, Threatened Abrupt Closure, Need for Urgent Coronary Artery Bypass Graft (CABG) Surgery, or Unsuccessful Procedure During the Index PCI | ClinicalTrials.gov |
| Description | (a patient could have multiple procedural events) | ClinicalTrials.gov |
| Time frame | during index PCI | ClinicalTrials.gov |
| Population | mITT (excluding STEMI) and based on available data | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | A Clinical Trial to Demonstrate the Efficacy of Cangrelor | ClinicalTrials.gov |
| NCT number | NCT00305162 | ClinicalTrials.gov |
| Phases | PHASE3 | ClinicalTrials.gov |
| Conditions | Myocardial Infarction (MI), Acute Coronary Syndromes (ACS) | ClinicalTrials.gov |
| Interventions | Cangrelor (P2Y12 inhibitor), clopidogrel (oral P2Y12 inhibitor), Placebo bolus & placebo infusion, Placebo capsules - end of infusion, Placebo capsules - as soon as possible after randomization | ClinicalTrials.gov |
| Lead sponsor | The Medicines Company | ClinicalTrials.gov |
| Results first posted | 2014-04-23 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT00305162?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.