Comparison · NCT00355082-eefbeddb
Lamotrigine Extended-release (LTG XR), 300 mg vs LTG XR, 250 mg: Number of Seizure-free Participants During the Last 12 Weeks of Treatment of the Treatment Phase
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Lamotrigine Extended-release (LTG XR), 300 mg vs LTG XR, 250 mg: Number of Seizure-free Participants During the Last 12 Weeks of Treatment of the Treatment Phase. Trial comparisons, record NCT00355082-eefbeddb. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00355082-eefbeddb
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.247 | 0.169 | 0.346 | wilson | |
| Risk in group 2 | 0.105 | 0.0543 | 0.194 | wilson | |
| Risk difference, group 1 minus group 2 | 0.142 | 0.0237 | 0.253 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.35 | 1.11 | 4.97 | log | |
| Odds ratio, group 1 over group 2 | 2.79 | 1.16 | 6.71 | log | |
| Number needed to treat, for one more participant with the outcome on Lamotrigine Extended-release (LTG XR), 300 mg than on LTG XR, 250 mg | 7.05 | 3.95 | 42.2 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Lamotrigine Extended-release (LTG XR), 300 mg | LTG XR, 300 mg/day | 22 | 89 | OG000 |
| Group 2 | LTG XR, 250 mg | LTG XR, 250 mg/day | 8 | 76 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Seizure-free Participants During the Last 12 Weeks of Treatment of the Treatment Phase
- Description
The number of participants who had no seizures during the treatment period was calculated. The last 12 weeks of treatment were either Weeks 11-22 or 12-23 depending on which background AED was being withdrawn
- Time frame
- The last 12 weeks of treatment of the Treatment phase (Monotherapy phase - approximately Week 11 through Week 23)
- Population
- All randomized participants who began withdrawal of background AED (Visit 5) minus any major protocol violators
Source ClinicalTrials.gov
Trial
- Title
- Conversion To Monotherapy With Lamictal Extended Release Tablets For Treatment Of Partial Epilepsy
- NCT number
- NCT00355082
- Phases
- PHASE3
- Conditions
- Epilepsy, Partial
- Interventions
- lamotrigine, 300 mg/day, lamotrigine, 250 mg/day
- Lead sponsor
- GlaxoSmithKline
- Results first posted
- 2009-11-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00355082?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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