Comparison · NCT00357903-sae
Total Adults vs Pediatric Subjects: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Total Adults vs Pediatric Subjects: serious adverse events. Trial comparisons, record NCT00357903-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00357903-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.504 | 0.464 | 0.545 | wilson | |
| Risk in group 2 | 0.276 | 0.178 | 0.402 | wilson | |
| Risk difference, group 1 minus group 2 | 0.228 | 0.0959 | 0.335 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.83 | 1.2 | 2.8 | log | |
| Odds ratio, group 1 over group 2 | 2.67 | 1.47 | 4.86 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Total Adults than on Pediatric Subjects | 4.38 | 2.99 | 10.4 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Total Adults | 293 | 581 | EG000 | |
| Group 2 | Pediatric Subjects | 16 | 58 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Up to 11.29 years
Source ClinicalTrials.gov
Trial
- Title
- Open-Label Extension Treatment With Etanercept (TNFR:Fc) for Participating Patients in Etanercept (TNFR:Fc) Clinical Trials
- NCT number
- NCT00357903
- Phases
- PHASE3
- Conditions
- Rheumatoid Arthritis
- Interventions
- Etanercept
- Lead sponsor
- Amgen
- Results first posted
- 2010-12-06
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00357903?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
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GET https://conductscience.org/api/comparisons/v1/NCT00357903-sae