Comparison · NCT00357968-cfdee6bf
Prasugrel vs Clopidogrel: Number of Hyporesponsive Participants at the End of the First Maintenance Dose Phase
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Prasugrel vs Clopidogrel: Number of Hyporesponsive Participants at the End of the First Maintenance Dose Phase. Trial comparisons, record NCT00357968-cfdee6bf. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00357968-cfdee6bf
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.025 | 0.00443 | 0.129 | wilson | |
| Risk in group 2 | 0.152 | 0.0757 | 0.282 | wilson | |
| Risk difference, group 1 minus group 2 | -0.127 | -0.259 | 0.00175 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.164 | 0.0211 | 1.28 | log | |
| Odds ratio, group 1 over group 2 | 0.143 | 0.0168 | 1.22 | log | |
| Number needed to treat, for one fewer participant with the outcome on Prasugrel than on Clopidogrel | 7.86 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Prasugrel | Patients randomized to a single oral loading dose (LD) of 60-mg prasugrel and placebo matched to clopidogrel (plus oral enteric coated aspirin 325 mg to 500 mg is recommended) followed by a 10-mg prasugrel and placebo matched to clopidogrel (prasugrel maintenance dose) taken orally once daily for 14 days. | 1 | 40 | OG000 |
| Group 2 | Clopidogrel | Patients randomized to a single oral loading dose (LD) of 600-mg clopidogrel and placebo matched to prasugrel (plus oral enteric coated aspirin 325 mg to 500 mg is recommended) followed by a 150-mg clopidogrel and placebo matched to prasugrel (clopidogrel maintenance dose) taken orally once daily for 14 days. | 7 | 46 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Hyporesponsive Participants at the End of the First Maintenance Dose Phase
- Description
- Number of patients with inhibition of platelet aggregation (IPA) with 20 uM adenosine diphosphate (ADP) \<20%
- Time frame
- From loading dose to day 15
- Population
Includes patients who received a single loading dose and had evaluable MPA measures, regardless of glycoprotein (GP) IIb/IIIa antagonist use. Patients had received 14 days of maintenance treatment but had not crossed-over to the alternate maintenance treatment.
Source ClinicalTrials.gov
Trial
- Title
- Trial in Subjects Undergoing Cardiac Catheterization With Planned Percutaneous Coronary Intervention With Stenting
- NCT number
- NCT00357968
- Phases
- PHASE2
- Conditions
- Coronary Artery Disease
- Interventions
- Prasugrel, Clopidogrel, Placebo for Prasugrel, Placebo for Clopidogrel
- Lead sponsor
- Eli Lilly and Company
- Results first posted
- 2010-08-09
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00357968?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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