Comparison · NCT00358579-85557135
Adrenaline vs Vasopressin: Return of Spontaneous Circulation.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Adrenaline vs Vasopressin: Return of Spontaneous Circulation. Trial comparisons, record NCT00358579-85557135. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00358579-85557135
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.3 | 0.255 | 0.35 | wilson | |
| Risk in group 2 | 0.318 | 0.273 | 0.367 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0179 | -0.0846 | 0.0493 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.944 | 0.759 | 1.17 | log | |
| Odds ratio, group 1 over group 2 | 0.92 | 0.671 | 1.26 | log | |
| Number needed to treat, for one fewer participant with the outcome on Adrenaline than on Vasopressin | 55.9 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Adrenaline | 1 mg Intravenous Adrenaline, administered as the first drug upon cardiac arrest patient's arrival at the Emergency Department | 106 | 353 | OG000 |
| Group 2 | Vasopressin | 40 IU Intravenous Vasopressin, administered as the first drug upon cardiac arrest patient's arrival at the Emergency Department | 119 | 374 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Return of Spontaneous Circulation.
- Description
Return of spontaneous circulation is defined as the presence of any palpable pulse detected by manual palpation of a major artery. This is measured as number of participants who had return of spontaneous circulation during resuscitation.
- Time frame
- during resuscitation
- Population
Source ClinicalTrials.gov
Trial
- Title
- Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
- NCT number
- NCT00358579
- Phases
- PHASE3
- Conditions
- Cardiac Arrest
- Interventions
- Adrenaline, Vasopressin
- Lead sponsor
- Singapore General Hospital
- Results first posted
- 2011-08-09
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00358579?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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