Comparison · NCT00359424-e3e871d2
Endovascular Therapy vs IV Rt-PA Alone: Symptomatic Intracranial Hemorrhage
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Endovascular Therapy vs IV Rt-PA Alone: Symptomatic Intracranial Hemorrhage. Trial comparisons, record NCT00359424-e3e871d2. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00359424-e3e871d2
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0622 | 0.0431 | 0.089 | wilson | |
| Risk in group 2 | 0.0586 | 0.0345 | 0.0976 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00365 | -0.0398 | 0.0396 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.06 | 0.559 | 2.02 | log | |
| Odds ratio, group 1 over group 2 | 1.07 | 0.539 | 2.11 | log | |
| Number needed to treat, for one more participant with the outcome on Endovascular Therapy than on IV Rt-PA Alone | 274 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Endovascular Therapy | Group two will receive a lower dose or a standard dose of IV rt-PA and then undergo an angiogram test (cerebral angiography) right after the medicine is given to check for blood clots. If a clot is not seen then no more treatment will be given. If a clot is seen, the neurointerventionalist will then choose (based on the location and extent of the blood clot) a protocol approved endovascular treatment given directly in the brain artery that will be most effective in reopening the blocked artery. | 27 | 434 | OG000 |
| Group 2 | IV Rt-PA Alone | Group one will receive the standard dose of intravenous (IV) rt-PA alone given over an hour. | 13 | 222 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Symptomatic Intracranial Hemorrhage
- Description
Symptomatic Intracranial Hemorrhage- Symptomatic ICH is defined as an intracranial hemorrhage temporally related to a decline in neurological status as well as new or worsening neurologic symptoms in the judgment of the clinical investigator and which may warrant medical intervention. These events are identified via Adverse Event CRF submitted by the site
- Time frame
- within the first 30 hours post IV rt-PA
- Population
- The intent-to-treat analysis sample includes all subjects who are randomized, and each subject is analyzed according to the treatment group to which they were randomly assigned.
Source ClinicalTrials.gov
Trial
- Title
- Interventional Management of Stroke (IMS) III Trial
- NCT number
- NCT00359424
- Phases
- PHASE3
- Conditions
- Stroke
- Interventions
- IV rt-PA alone, endovascular therapy
- Lead sponsor
- Joseph Broderick
- Results first posted
- 2013-12-13
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00359424?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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