Comparison · NCT00421603-4d6bf321
Adderall-XR and Topiramate vs Placebo: Three Weeks of Continuous Cocaine Abstinence as Measured by Urine Toxicology and Self Report Based on Time Line Follow Back
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Adderall-XR and Topiramate vs Placebo: Three Weeks of Continuous Cocaine Abstinence as Measured by Urine Toxicology and Self Report Based on Time Line Follow Back. Trial comparisons, record NCT00421603-4d6bf321. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00421603-4d6bf321
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.333 | 0.206 | 0.49 | wilson | |
| Risk in group 2 | 0.167 | 0.0832 | 0.306 | wilson | |
| Risk difference, group 1 minus group 2 | 0.167 | -0.0219 | 0.344 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2 | 0.891 | 4.49 | log | |
| Odds ratio, group 1 over group 2 | 2.5 | 0.875 | 7.14 | log | |
| Number needed to treat, for one more participant with the outcome on Adderall-XR and Topiramate than on Placebo | 6 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Adderall-XR and Topiramate | Adderall-XR doses were titrated over two weeks to a maximum dose of 60 mg daily and topiramate doses were titrated over six weeks to a maximum dose of 150 mg twice daily. | 13 | 39 | OG000 |
| Group 2 | Placebo | Placebo daily dose | 7 | 42 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Three Weeks of Continuous Cocaine Abstinence as Measured by Urine Toxicology and Self Report Based on Time Line Follow Back
- Description
Cocaine use was assessed by using urine toxicology confirmed self-report. Self-reported cocaine use data was collected for each day of the study period by the Time Line Follow Back. Urine samples were collected three times per week. A week was considered abstinence if no cocaine use was self reported during that week and if all urine samples collected that week were negative for cocaine. If a patient achieved three continuous weeks of abstinence based on this criteria they were considered cocaine abstinent in terms of this outcome measure.
- Time frame
- 3 weeks of abstinence during 14 weeks of trial or for length of participation
- Population
Source ClinicalTrials.gov
Trial
- Title
- A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence
- NCT number
- NCT00421603
- Phases
- PHASE2
- Conditions
- Cocaine Dependence
- Interventions
- Adderall-XR and Topiramate, Placebo
- Lead sponsor
- New York State Psychiatric Institute
- Results first posted
- 2013-02-28
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00421603?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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