Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): Myocardial Infarction (MI)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.0617 | 0.0542 | 0.0702 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.0624 | 0.0549 | 0.0709 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.000683 | -0.012 | 0.0107 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.989 | 0.824 | 1.19 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.988 | 0.814 | 1.2 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with the outcome on Nitrous Oxide: 70% N2O (FiO2 0.3) than on N2O Free Group (FiO2 0.3) | 1,470 | from the risk difference interval | the interval includes no difference | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Nitrous Oxide: 70% N2O (FiO2 0.3) | N2O Group (FiO2 0.3)~Nitrous Oxide: 70% N2O V's No N2O~Nitrous Oxide: N2O 70% v's No N2O | 215 | 3,483 | OG000 | ClinicalTrials.gov |
| Group 2 | N2O Free Group (FiO2 0.3) | N2O free group (FiO2 0.3)~Nitrous Oxide: 70% N2O V's No N2O~Nitrous Oxide: N2O 70% v's No N2O | 219 | 3,509 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | SECONDARY | ClinicalTrials.gov |
| Title | Myocardial Infarction (MI) | ClinicalTrials.gov |
| Description | ClinicalTrials.gov | |
| Time frame | 30 days post op | ClinicalTrials.gov |
| Population | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial | ClinicalTrials.gov |
| NCT number | NCT00430989 | ClinicalTrials.gov |
| Phases | PHASE4 | ClinicalTrials.gov |
| Conditions | Coronary Artery Disease | ClinicalTrials.gov |
| Interventions | Nitrous Oxide, No Nitrous Oxide | ClinicalTrials.gov |
| Lead sponsor | Bayside Health | ClinicalTrials.gov |
| Results first posted | 2019-06-17 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT00430989?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.