Nitrous Oxide: 70% N2O (FiO2 0.3) vs N2O Free Group (FiO2 0.3): The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured at 30 Days After Surgery.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.0813 | 0.0726 | 0.0908 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.0844 | 0.0756 | 0.094 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.0031 | -0.016 | 0.00984 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.963 | 0.824 | 1.13 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.96 | 0.81 | 1.14 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with the outcome on Nitrous Oxide: 70% N2O (FiO2 0.3) than on N2O Free Group (FiO2 0.3) | 322 | from the risk difference interval | the interval includes no difference | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Nitrous Oxide: 70% N2O (FiO2 0.3) | N2O Group (FiO2 0.3)~Nitrous Oxide: 70% N2O V's No N2O~Nitrous Oxide: N2O 70% v's No N2O | 283 | 3,483 | OG000 | ClinicalTrials.gov |
| Group 2 | N2O Free Group (FiO2 0.3) | N2O free group (FiO2 0.3)~Nitrous Oxide: 70% N2O V's No N2O~Nitrous Oxide: N2O 70% v's No N2O | 296 | 3,509 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | PRIMARY | ClinicalTrials.gov |
| Title | The Primary Endpoint is a Composite of Death and Cardiovascular Events (Clinical and Silent MI, Cardiac Failure, Cardiac Arrest, Pulmonary Embolism, and Stroke) Measured at 30 Days After Surgery. | ClinicalTrials.gov |
| Description | ClinicalTrials.gov | |
| Time frame | 30 days post op | ClinicalTrials.gov |
| Population | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial | ClinicalTrials.gov |
| NCT number | NCT00430989 | ClinicalTrials.gov |
| Phases | PHASE4 | ClinicalTrials.gov |
| Conditions | Coronary Artery Disease | ClinicalTrials.gov |
| Interventions | Nitrous Oxide, No Nitrous Oxide | ClinicalTrials.gov |
| Lead sponsor | Bayside Health | ClinicalTrials.gov |
| Results first posted | 2019-06-17 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT00430989?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.