Comparison · NCT00443599-e3369a85
Tight Glycemic Control vs Standard Care: Mortality at 30 Days.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Tight Glycemic Control vs Standard Care: Mortality at 30 Days. Trial comparisons, record NCT00443599-e3369a85. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00443599-e3369a85
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0102 | 0.00438 | 0.0238 | wilson | |
| Risk in group 2 | 0.0124 | 0.00569 | 0.0268 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00215 | -0.0177 | 0.0129 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.827 | 0.254 | 2.69 | log | |
| Odds ratio, group 1 over group 2 | 0.825 | 0.25 | 2.72 | log | |
| Number needed to treat, for one fewer participant with the outcome on Tight Glycemic Control than on Standard Care | 465 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: standard care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Tight Glycemic Control | Insulin was infused to target a blood glucose concentration of 80-110 mg/dL.~Insulin: Study drug is continuously infused intravenous insulin. Suggested dose is calculated by a computerized infusion algorithm using the participant's blood sugar concentration. The insulin infusion rate is titrated to maintain normal blood sugar. Participants are eligible to receive insulin while they have an in-dwelling arterial catheter. | 5 | 488 | OG000 |
| Group 2 | Standard Care | Insulin was infused according to the discretion of the treating clinical team.~Usual Care: Participants receive standard Cardiac ICU care without tight blood glucose control. | 6 | 484 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Mortality at 30 Days.
- Description
- Mortality is assessed at hospital discharge and at 30 days. If the participant is discharged from the hospital prior to 30 days, status is determined by a follow-up phone call to the family.
- Time frame
- Measured at 30 days.
- Population
- This outcome was not measured for participants lost to follow-up at 30 days post cardiac surgery.
Source ClinicalTrials.gov
Trial
- Title
- SPECS: Safe Pediatric Euglycemia in Cardiac Surgery
- NCT number
- NCT00443599
- Phases
- NA
- Conditions
- Heart Defects, Congenital, Hyperglycemia
- Interventions
- Insulin, Usual Care
- Lead sponsor
- Boston Children's Hospital
- Results first posted
- 2014-03-10
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00443599?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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