LNG IUS vs Copper IUD: Contraceptive Failure
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.000604 | 0.000412 | 0.000884 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.00501 | 0.00409 | 0.00614 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.0044 | -0.00555 | -0.00344 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.121 | 0.078 | 0.186 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.12 | 0.0776 | 0.185 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with the outcome on LNG IUS than on Copper IUD | 227 | 180 | 291 | from the risk difference interval | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | LNG IUS | New users of Mirena® IUS | 26 | 43,078 | OG000 | ClinicalTrials.gov |
| Group 2 | Copper IUD | New users of Copper IUD | 92 | 18,370 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | OTHER_PRE_SPECIFIED | ClinicalTrials.gov |
| Title | Contraceptive Failure | ClinicalTrials.gov |
| Description | Intrauterine contraceptive methods have low Pearl Indices. Nevertheless, there is a lack of comparative data between LNG IUS users and copper IUD users. Women with unintended pregnancies were explicitly aked whether the pregnancy occured despite IUD use. The 29 pregnancies that occured after unrecognized IUD expulsion were considered to have resulted from a failure of the contraceptive method and were therefore included in the analysis. | ClinicalTrials.gov |
| Time frame | Within 12 months | ClinicalTrials.gov |
| Population | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | European Active Surveillance Study for Intrauterine Devices | ClinicalTrials.gov |
| NCT number | NCT00461175 | ClinicalTrials.gov |
| Phases | ClinicalTrials.gov | |
| Conditions | Uterine Perforation | ClinicalTrials.gov |
| Interventions | ClinicalTrials.gov | |
| Lead sponsor | Center for Epidemiology and Health Research, Germany | ClinicalTrials.gov |
| Results first posted | 2014-10-22 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT00461175?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.