LNG IUD vs Cu-IUD: Breast Cancer Risk
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.201 | 0.191 | 0.212 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.197 | 0.186 | 0.208 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | 0.00451 | -0.0106 | 0.0196 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 1.02 | 0.948 | 1.1 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 1.03 | 0.936 | 1.13 | log | ClinicalTrials.gov | |
| Number needed to treat, for one more participant with the outcome on LNG IUD than on Cu-IUD | 222 | from the risk difference interval | the interval includes no difference | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | LNG IUD | Women who currently or ever used a LNG IUDs (Mirena) at time of breast cancer diagnosis | 1,076 | 5,346 | OG000 | ClinicalTrials.gov |
| Group 2 | Cu-IUD | Women who currently or ever used a copper IUDs at time of breast cancer diagnosis | 1,068 | 5,428 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | PRIMARY | ClinicalTrials.gov |
| Title | Breast Cancer Risk | ClinicalTrials.gov |
| Description | Breast cancer (invasive carcinoma or carcinoma in situ) in women aged \<50 years at diagnosis. Cases were excluded if they had died before study start or had a history of malignancy. | ClinicalTrials.gov |
| Time frame | retrospective, January 2000 to December 2007 | ClinicalTrials.gov |
| Population | Frequency of breast cancer (in situ and invasive) in LNG-IUD users and Cu-IUD users | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | Case-Control-Study on the Breast Cancer Risk of Mirena® Compared With Copper IUDs | ClinicalTrials.gov |
| NCT number | NCT00461253 | ClinicalTrials.gov |
| Phases | ClinicalTrials.gov | |
| Conditions | Breast Cancer | ClinicalTrials.gov |
| Interventions | Levonorgestrel-releasing IUD, Copper IUD | ClinicalTrials.gov |
| Lead sponsor | Center for Epidemiology and Health Research, Germany | ClinicalTrials.gov |
| Results first posted | 2016-01-25 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT00461253?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.