Comparison · NCT00481247-589306dd
Dasatinib vs Imatinib: Number of Participants With Best Confirmed Complete Cytogenetic Response (cCCyR) Within 12 Months
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Dasatinib vs Imatinib: Number of Participants With Best Confirmed Complete Cytogenetic Response (cCCyR) Within 12 Months. Trial comparisons, record NCT00481247-589306dd. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00481247-589306dd
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.788 | 0.734 | 0.833 | wilson | |
| Risk in group 2 | 0.681 | 0.622 | 0.734 | wilson | |
| Risk difference, group 1 minus group 2 | 0.107 | 0.0309 | 0.181 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.16 | 1.04 | 1.28 | log | |
| Odds ratio, group 1 over group 2 | 1.74 | 1.17 | 2.58 | log | |
| Number needed to treat, for one more participant with the outcome on Dasatinib than on Imatinib | 9.36 | 5.52 | 32.4 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Dasatinib | Tablets, oral, dasatinib 100 mg once daily (QD) | 204 | 259 | OG000 |
| Group 2 | Imatinib | Tablets, oral, imatinib 400 mg once daily (QD) | 177 | 260 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With Best Confirmed Complete Cytogenetic Response (cCCyR) Within 12 Months
- Description
Cytogenetic response (CyR) is based on the prevalence of Philadelphia positive (Ph+) cells in metaphase from bone marrow (BM) sample. (Ideally, 25 metaphases but at least 20 metaphases from a BM sample were evaluated). Complete Cytogenetic Response (CCyR)=0% Ph+ cells in metaphase in BM. A cCCyR=those in which all measurements up to at least 28 days after the initial response show an equivalent or better CCyR.
- Time frame
- Pretreatment, every 3 months up to 12 months
- Population
- All randomized participants
Source ClinicalTrials.gov
Trial
- Title
- A Phase III Study of Dasatinib vs Imatinib in Patients With Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia
- NCT number
- NCT00481247
- Phases
- PHASE3
- Conditions
- Myeloid Leukemia, Chronic
- Interventions
- Dasatinib, Imatinib
- Lead sponsor
- Bristol-Myers Squibb
- Results first posted
- 2011-03-15
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00481247?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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