Comparison · NCT00584948-sae
Memantine vs Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Memantine vs Placebo: serious adverse events. Trial comparisons, record NCT00584948-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00584948-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0426 | 0.0117 | 0.142 | wilson | |
| Risk in group 2 | 0.0638 | 0.0219 | 0.172 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0213 | -0.133 | 0.0871 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.667 | 0.117 | 3.81 | log | |
| Odds ratio, group 1 over group 2 | 0.652 | 0.104 | 4.09 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Memantine than on Placebo | 47 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Memantine | Week 1: Take 5mg tab every morning. Week 2: Take 5mg tab every morning and evening. Week 3: Take 10mg tab in the morning and 5 mg in the evening. Week 4: Take 10 mg tab in the morning and evening, and remain on this dose through the remainder of the study. | 2 | 47 | EG000 |
| Group 2 | Placebo | Week 1: Take 5mg tab every morning. Week 2: Take 5mg tab every morning and evening. Week 3: Take 10mg tab in the morning and 5 mg in the evening. Week 4: Take 10 mg tab in the morning and evening, and remain on this dose through the remainder of the study | 3 | 47 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
Source ClinicalTrials.gov
Trial
- Title
- Memantine Treatment in Fragile X-Associated Tremor/Ataxia Syndrome
- NCT number
- NCT00584948
- Phases
- NA
- Conditions
- Fragile X-Associated Tremor/Ataxia Syndrome, Fragile X Premutation Carriers
- Interventions
- Memantine, Placebo
- Lead sponsor
- University of California, Davis
- Results first posted
- 2017-04-10
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00584948?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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