A - Coenzyme Q10 2400 mg/Day vs B - Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.251 | 0.205 | 0.303 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.271 | 0.224 | 0.324 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.0204 | -0.0898 | 0.0493 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.925 | 0.708 | 1.21 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.9 | 0.626 | 1.29 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with a serious adverse event on A - Coenzyme Q10 2400 mg/Day than on B - Placebo | 49 | from the risk difference interval | the interval includes no difference | ClinicalTrials.gov |
Groups 2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | A - Coenzyme Q10 2400 mg/Day | Randomized to active treatment (coenzyme Q10 2400 mg/day)~coenzyme Q10: 4 - 300 mg CoQ chewable wafers taken orally twice a day | 76 | 303 | EG000 | ClinicalTrials.gov |
| Group 2 | B - Placebo | Randomized to placebo~placebo: an inactive substance | 83 | 306 | EG001 | ClinicalTrials.gov |
Harm 2
| Field | Value | Source |
|---|---|---|
| What it counts | Total, serious adverse events | ClinicalTrials.gov |
| Time frame | 5 years | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | Coenzyme Q10 in Huntington's Disease (HD) | ClinicalTrials.gov |
| NCT number | NCT00608881 | ClinicalTrials.gov |
| Phases | PHASE3 | ClinicalTrials.gov |
| Conditions | Huntington's Disease | ClinicalTrials.gov |
| Interventions | coenzyme Q10, placebo | ClinicalTrials.gov |
| Lead sponsor | Massachusetts General Hospital | ClinicalTrials.gov |
| Results first posted | 2016-03-30 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT00608881?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.