Comparison · NCT00619359-8f7f8770
Fosaprepitant vs Aprepitant: A Complete Response (no Vomiting and no Use of Rescue Therapy) Overall (in the 120 Hours Following Initiation of Cisplatin).
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Fosaprepitant vs Aprepitant: A Complete Response (no Vomiting and no Use of Rescue Therapy) Overall (in the 120 Hours Following Initiation of Cisplatin). Trial comparisons, record NCT00619359-8f7f8770. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00619359-8f7f8770
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.719 | 0.692 | 0.745 | wilson | |
| Risk in group 2 | 0.723 | 0.696 | 0.748 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0043 | -0.0414 | 0.0328 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.994 | 0.944 | 1.05 | log | |
| Odds ratio, group 1 over group 2 | 0.979 | 0.814 | 1.18 | log | |
| Number needed to treat, for one fewer participant with the outcome on Fosaprepitant than on Aprepitant | 233 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Fosaprepitant | Fosaprepitant dimeglumine 150 mg IV, ondansetron 32 mg IV, and dexamethasone 12 mg by mouth (PO) on Day 1, dexamethasone 8 mg PO on Day 2, and dexamethasone 16 mg PO on Days 3 and 4. | 795 | 1,106 | OG000 |
| Group 2 | Aprepitant | Aprepitant 125 mg by mouth (PO), ondansetron 32 mg IV, and dexamethasone 12 mg PO on Day 1, aprepitant 80 mg PO and dexamethasone 8 mg PO on Days 2 and 3, dexamethasone 8 mg PO on Day 4. | 820 | 1,134 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- A Complete Response (no Vomiting and no Use of Rescue Therapy) Overall (in the 120 Hours Following Initiation of Cisplatin).
- Description
- The number of patients who reported No Vomiting and No Use of Rescue Therapy in the 120 hours following initiation of cisplatin chemotherapy.
- Time frame
- Overall (in the 120 hours following initiation of cisplatin chemotherapy).
- Population
FAS (Full Analysis Set) patient population was used for all efficacy evaluations and included patients who: 1) received at least one dose of study therapy, 2) received cisplatin chemotherapy, and 3) had at least one post-treatment efficacy assessment.
Source ClinicalTrials.gov
Trial
- Title
- Evaluation of Fosaprepitant (MK0517) in Single Dose Schedule (0517-017)
- NCT number
- NCT00619359
- Phases
- PHASE3
- Conditions
- Chemotherapy-Induced Nausea and Vomiting (CINV)
- Interventions
- Comparator: fosaprepitant dimeglumine, Comparator: Aprepitant, Dexamethasone, Dexamethasone, Ondansetron
- Lead sponsor
- Merck Sharp & Dohme LLC
- Results first posted
- 2010-02-12
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00619359?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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