Comparison · NCT00619359-sae
Fosaprepitant vs Aprepitant: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Fosaprepitant vs Aprepitant: serious adverse events. Trial comparisons, record NCT00619359-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00619359-sae
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.129 | 0.111 | 0.15 | wilson | |
| Risk in group 2 | 0.134 | 0.116 | 0.155 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00482 | -0.0324 | 0.0229 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.964 | 0.782 | 1.19 | log | |
| Odds ratio, group 1 over group 2 | 0.959 | 0.753 | 1.22 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Fosaprepitant than on Aprepitant | 208 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Fosaprepitant | Fosaprepitant dimeglumine 150 mg IV, ondansetron 32 mg IV, and dexamethasone 12 mg by mouth (PO) on Day 1, dexamethasone 8 mg PO on Day 2, and dexamethasone 16 mg PO on Days 3 and 4.~4 patients from the fosaprepitant regimen were randomized to the study, but discontinued before receiving study drug. These patients were excluded from the Adverse Event tables. | 148 | 1,143 | EG000 |
| Group 2 | Aprepitant | Aprepitant 125 mg by mouth (PO), ondansetron 32 mg IV, and dexamethasone 12 mg PO on Day 1, aprepitant 80 mg PO and dexamethasone 8 mg PO on Days 2 and 3, dexamethasone 8 mg PO on Day 4.~6 patients from the aprepitant regimen were randomized to the study, but discontinued before receiving study drug. These patients were excluded from the Adverse Event tables. | 157 | 1,169 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- AEs were collected starting from the Pre-Study Visit (Day -30 to Day -1) up to 14 days after the patient's last dose of study drug.
Source ClinicalTrials.gov
Trial
- Title
- Evaluation of Fosaprepitant (MK0517) in Single Dose Schedule (0517-017)
- NCT number
- NCT00619359
- Phases
- PHASE3
- Conditions
- Chemotherapy-Induced Nausea and Vomiting (CINV)
- Interventions
- Comparator: fosaprepitant dimeglumine, Comparator: Aprepitant, Dexamethasone, Dexamethasone, Ondansetron
- Lead sponsor
- Merck Sharp & Dohme LLC
- Results first posted
- 2010-02-12
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00619359?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT00619359-sae