Comparison · NCT00625404-2bcaa64c
Truvada Arm vs Placebo Arm: HIV Infection
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Truvada Arm vs Placebo Arm: HIV Infection. Trial comparisons, record NCT00625404-2bcaa64c. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00625404-2bcaa64c
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0322 | 0.023 | 0.0449 | wilson | |
| Risk in group 2 | 0.0339 | 0.0245 | 0.0468 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00169 | -0.0175 | 0.0141 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.95 | 0.595 | 1.52 | log | |
| Odds ratio, group 1 over group 2 | 0.949 | 0.585 | 1.54 | log | |
| Number needed to treat, for one fewer participant with the outcome on Truvada Arm than on Placebo Arm | 592 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Truvada Arm | The effectiveness population consisted of all women who were randomized and who had at least one follow-up visit and were not HIV PCR positive at enrollment. This population consisted of 2056 women (1024 in the Truvada arm, 1032 in the placebo arm) and was used for baseline analyses. | 33 | 1,024 | OG000 |
| Group 2 | Placebo Arm | The effectiveness population consisted of all women who were randomized and who had at least one follow-up visit and were not HIV PCR positive at enrollment. This population consisted of 2056 women (1024 in the Truvada arm, 1032 in the placebo arm) and was used for baseline analyses. | 35 | 1,032 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- HIV Infection
- Description
- HIV Seroconversion, with time to infection refined based on PCR results obtained from stored specimens.
- Time frame
- Cumulative HIV infection between enrollment and 52 weeks
- Population
- All randomized participants who made at least one follow-up visit and were not HIV-positive at enrollment were included in the analysis population
Source ClinicalTrials.gov
Trial
- Title
- FEM-PrEP (Truvada®): Study to Assess the Role of Truvada® in Preventing HIV Acquisition in Women
- NCT number
- NCT00625404
- Phases
- PHASE3
- Conditions
- HIV Infections
- Interventions
- Truvada, Placebo
- Lead sponsor
- FHI 360
- Results first posted
- 2014-04-16
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00625404?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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