Comparison · NCT00638690-512edbf0
Abiraterone Acetate vs Placebo: Number of Patients Achieving a Prostate-Specific Antigen Decline >=50%
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Abiraterone Acetate vs Placebo: Number of Patients Achieving a Prostate-Specific Antigen Decline >=50%. Trial comparisons, record NCT00638690-512edbf0. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00638690-512edbf0
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.291 | 0.261 | 0.324 | wilson | |
| Risk in group 2 | 0.0553 | 0.0368 | 0.0823 | wilson | |
| Risk difference, group 1 minus group 2 | 0.236 | 0.195 | 0.273 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 5.27 | 3.46 | 8.02 | log | |
| Odds ratio, group 1 over group 2 | 7.02 | 4.45 | 11.1 | log | |
| Number needed to treat, for one more participant with the outcome on Abiraterone Acetate than on Placebo | 4.24 | 3.66 | 5.13 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Abiraterone Acetate | Abiraterone acetate plus prednisone/prednisolone administered as four 250 mg tablets of abiraterone acetate once daily plus 5 mg prednisone/5 mg prednisolone twice daily until disease progression. | 232 | 797 | OG000 |
| Group 2 | Placebo | Placebo plus prednisone/prednisolone administered as four placebo tablets once daily plus 5 mg prednisone/5 mg prednisolone tablet twice daily until disease progression. | 22 | 398 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Patients Achieving a Prostate-Specific Antigen Decline >=50%
- Description
- A prostate-specific antigen (PSA) response was defined as a \>=50% decline from baseline.
- Time frame
- Up to 12 months
- Population
Analysis was performed on the Intent-to-Treat (ITT) population. The ITT population is composed of all patients randomized into the study and who will be classified according to their assigned teatment group, regardless of the actual treatment received.
Source ClinicalTrials.gov
Trial
- Title
- Abiraterone Acetate in Castration-Resistant Prostate Cancer Previously Treated With Docetaxel-Based Chemotherapy
- NCT number
- NCT00638690
- Phases
- PHASE3
- Conditions
- Prostatic Neoplasms
- Interventions
- Placebo, Abiraterone acetate, Prednisone/prednisolone
- Lead sponsor
- Cougar Biotechnology, Inc.
- Results first posted
- 2013-05-16
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00638690?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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