Comparison · NCT00645099-8a7a48a3
Paliperidone ER vs Olanzapine: Number of Patients First Meeting the NCEP/ATP III Criteria for Metabolic Syndrome During Follow-up
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Paliperidone ER vs Olanzapine: Number of Patients First Meeting the NCEP/ATP III Criteria for Metabolic Syndrome During Follow-up. Trial comparisons, record NCT00645099-8a7a48a3. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT00645099-8a7a48a3
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.132 | 0.0897 | 0.191 | wilson | |
| Risk in group 2 | 0.233 | 0.175 | 0.304 | wilson | |
| Risk difference, group 1 minus group 2 | -0.101 | -0.183 | -0.0185 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.567 | 0.354 | 0.909 | log | |
| Odds ratio, group 1 over group 2 | 0.501 | 0.284 | 0.886 | log | |
| Number needed to treat, for one fewer participant with the outcome on Paliperidone ER than on Olanzapine | 9.91 | 5.45 | 54.2 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Paliperidone ER | 6-mg or 9-mg tablet once daily flexible dosing for 6 months | 23 | 174 | OG000 |
| Group 2 | Olanzapine | 10-15 mg (using 5-mg or 10-mg tablets) once daily flexible dosing for 6 months | 38 | 163 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Patients First Meeting the NCEP/ATP III Criteria for Metabolic Syndrome During Follow-up
- Description
Metabolic syndrome is defined according the Third Report of the National Cholesterol Education Program Expert Panel on~Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP/ATPIII) of which 3 out of 5 criteria must be met:~* waist circumference men \> 102 cm; waist circumference women \> 88 cm~* TG ≥ 150 mg/dL~* HDL cholesterol men \<40 mg/dL; HDL cholesterol women \<50 mg/dL~* Blood pressure systolic ≥ 130 mmHg; Blood pressure diastolic ≥ 85 mmHg~* Fasting glucose ≥ 110 mg /dL
- Time frame
- 6 months
- Population
The secondary endpoint analysis set included all patients who received study medication at least once and provided ≥1 post-baseline efficacy measurement. In this case, the total number of patients in the analysis set depends on the number of patients without metabolic syndrome at baseline.
Source ClinicalTrials.gov
Trial
- Title
- A 6 Month Study to Compare the Metabolic Effects of Paliperidone ER and Olanzapine in Patients With Schizophrenia
- NCT number
- NCT00645099
- Phases
- PHASE3
- Conditions
- Schizophrenia
- Interventions
- olanzapine, paliperidone ER
- Lead sponsor
- Janssen-Cilag International NV
- Results first posted
- 2010-07-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT00645099?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT00645099-8a7a48a3